Synthesis and evaluation of acyl-AMP phosphate isosteres as inhibitors of fungal acetyl CoA synthetase

This work was supported by NIH grants 5R01AI161973 (D.J.K), T32AI007511 (A.J.J) This project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. 75N93022C00036. This research used resources from the NYX beamline 19-ID, supported by the New York Structural Biology Center, at the National Synchrotron Light Source II, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Brookhaven National Laboratory under Contract No. DE-SC0012704. The NYX detector instrumentation was supported by grant S10OD030394 through the Office of the Director of the National Institutes of Health. This research used resources from the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. Use of the LS-CAT Sector 21 was supported by the Michigan Economic Development Corporation and the Michigan Technology Tri-Corridor (Grant 085P1000817). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The purchase of the NMR spectrometer used to obtain results included in this publication was supported by the National Science Foundation under the MRI award CHE-2117776 (T.J.H). The HRMS was supported by Northern Illinois University's Molecular Analysis Core Laboratory, RRID:SCR_024586, which was established in partnership with Shimadzu Scientific Instruments. Purchase of the Bruker Maxis Plus QTOF was made possible by the National Science Foundation under Grant No. 1726931.