Journal article
Synthesis and structure activity relationships of schweinfurthin indoles
Bioorganic & medicinal chemistry, Vol.22(8), pp.2542-2552
04/15/2014
DOI: 10.1016/j.bmc.2014.02.043
PMCID: PMC4030441
PMID: 24656801
Abstract
As part of a program to explore the biological activity of analogues of the natural schweinfurthins, a set of compounds has been prepared where an indole system can be viewed as a substitution for the resorcinol substructure of the schweinfurthin’s D-ring. Twelve of these schweinfurthin indoles have been prepared and evaluated in the 60 cell line screen of the National Cancer Institute. While a range of activity has been observed, it is now clear that schweinfurthin indoles can demonstrate the intriguing pattern of activity associated with the natural stilbenes. In the best cases, these indole analogues display both potency and differential activity across the various cell lines comparable to the best resorcinol analogues.
Details
- Title: Subtitle
- Synthesis and structure activity relationships of schweinfurthin indoles
- Creators
- John G Kodet - Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, United StatesJohn A Beutler - Molecular Targets Laboratory, Center for Cancer Research, NCI-Frederick, Frederick, MD 21702, United StatesDavid F Wiemer - Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, United States
- Resource Type
- Journal article
- Publication Details
- Bioorganic & medicinal chemistry, Vol.22(8), pp.2542-2552
- DOI
- 10.1016/j.bmc.2014.02.043
- PMID
- 24656801
- PMCID
- PMC4030441
- NLM abbreviation
- Bioorg Med Chem
- ISSN
- 0968-0896
- eISSN
- 1464-3391
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 04/15/2014
- Academic Unit
- Neuroscience and Pharmacology; Chemistry
- Record Identifier
- 9983985828602771
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