Journal article
Synthesis and structure of N1-e-benzo-4,7,13,16,21,26-hexaoxa-1,10-diazabicyclo[8.8.8]hexacos-23-yl-N2-phenylthiourea. Derivative of a bifunctional complexing agent
Journal of heterocyclic chemistry, Vol.29(4), pp.877-881
07/1992
DOI: 10.1002/jhet.5570290434
Abstract
A cryptand with an aminobenzo group 4,7,13,16,21,24-hexaoxa-5,6-(4′-aminobenzo)-1,10-diazabicyclo-[8.8.8]hexacosane, has been synthesized as a bifunctional complexing intermediate for investigation of the labeling of proteins with metal radionuclides. This amine, although unstable, can be prepared as the stable stannic salt. The free base was converted to the corresponding phenylthiourea by 1) reaction with phenyliso-thiocyanate and 2) conversion to its isothiocyanate followed by reaction with aniline. The thiourea structure was confirmed by X-ray crystallographic analysis.
Details
- Title: Subtitle
- Synthesis and structure of N1-e-benzo-4,7,13,16,21,26-hexaoxa-1,10-diazabicyclo[8.8.8]hexacos-23-yl-N2-phenylthiourea. Derivative of a bifunctional complexing agent
- Creators
- William A. Pettit - Iowa City VA Medical CenterYoshihisa Iwai - University of IowaCharles F. Barfknecht - University of IowaDale C. Swenson - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of heterocyclic chemistry, Vol.29(4), pp.877-881
- Publisher
- Wiley-Blackwell
- DOI
- 10.1002/jhet.5570290434
- ISSN
- 0022-152X
- eISSN
- 1943-5193
- Number of pages
- 5
- Language
- English
- Date published
- 07/1992
- Academic Unit
- Chemistry; Pharmacy
- Record Identifier
- 9984622048202771