Journal article
Synthesis of Chiral Amines by C–C Bond Formation with Photoredox Catalysis
Synthesis (Stuttgart), Vol.53(14), pp.2319-2341
07/20/2021
DOI: 10.1055/a-1396-8343
Abstract
Abstract
Chiral amines are key substructures of biologically active natural products and drug candidates. The advent of photoredox catalysis has changed the way synthetic chemists think about building these substructures, opening new pathways that were previously unavailable. New developments in this area are reviewed, with an emphasis on C–C bond constructions involving radical intermediates generated through photoredox processes.
1 Introduction
2 Radical–Radical Coupling of α-Amino Radicals
2.1 Radical–Radical Coupling Involving Amine Oxidation
2.2 Radical–Radical Coupling Involving Imine Reduction
2.3 Couplings Involving both Amine Oxidation and Imine Reduction
3 Addition Reactions of α-Amino Radicals
3.1 Conjugate Additions of α-Amino Radicals
3.2 Addition of α-Amino Radicals to Heteroaromatic Systems
3.3 Cross Coupling via Additions to Transition Metal Complexes
4 Radical Addition to C=N Bonds Using Photoredox Catalysis
4.1 Intramolecular Radical Addition to C=N Bonds
4.2 Intermolecular Radical Addition to C=N Bonds
5 Conclusion
Details
- Title: Subtitle
- Synthesis of Chiral Amines by C–C Bond Formation with Photoredox Catalysis
- Creators
- Stephen T. J CullenGregory K Friestad - Department of Chemistry, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Synthesis (Stuttgart), Vol.53(14), pp.2319-2341
- Publisher
- Georg Thieme Verlag KG
- DOI
- 10.1055/a-1396-8343
- ISSN
- 0039-7881
- eISSN
- 1437-210X
- Grant note
- CHE-1362111 / National Science Foundation T32 GM067795 / National Institute of General Medical Sciences University of Iowa
- Language
- English
- Date published
- 07/20/2021
- Academic Unit
- Chemistry
- Record Identifier
- 9984216599002771
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