Journal article
Synthesis of a DOTA--biotin conjugate for radionuclide chelation via Cu-free click chemistry
Organic letters, Vol.12(10), pp.2398-2401
05/21/2010
DOI: 10.1021/ol100774p
PMCID: PMC5506828
PMID: 20423109
Abstract
A strain-induced copper-free click reaction mediated by a new and easily prepared cyclooctyne derivative was used to efficiently assemble a DOTA-biotin adduct capable of radionuclide ((68)Ga) uptake. This synthetic strategy offers a potentially general and convenient means of preparing targeted radiolabeling and radiotherapeutic agents.
Details
- Title: Subtitle
- Synthesis of a DOTA--biotin conjugate for radionuclide chelation via Cu-free click chemistry
- Creators
- Michael K Schultz - Department of Radiology and Radiation Oncology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA. michael-schultz@uiowa.eduSharavathi G ParameswarappaF Christopher Pigge
- Resource Type
- Journal article
- Publication Details
- Organic letters, Vol.12(10), pp.2398-2401
- DOI
- 10.1021/ol100774p
- PMID
- 20423109
- PMCID
- PMC5506828
- NLM abbreviation
- Org Lett
- ISSN
- 1523-7052
- eISSN
- 1523-7052
- Publisher
- United States
- Grant note
- L40 CA208954 / NCI NIH HHS
- Language
- English
- Date published
- 05/21/2010
- Academic Unit
- Radiology; Stead Family Department of Pediatrics; Radiation Oncology; Chemistry
- Record Identifier
- 9983985999502771
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