Journal article
Synthesis of a novel photopolymerized nanocomposite hydrogel for treatment of acute mechanical damage to cartilage
Acta biomaterialia, Vol.7(8), pp.3094-3100
2011
DOI: 10.1016/j.actbio.2011.04.010
PMCID: PMC4950507
PMID: 21530694
Abstract
Intra-articular fractures initiate a cascade of pathobiological and pathomechanical events that culminate in post-traumatic osteoarthritis (PTOA). Hallmark features of PTOA include destruction of the cartilage matrix in combination with loss of chondrocytes and acute mechanical damage (AMD). Currently, treatment of intra-articular fractures essentially focuses completely on restoration of the macroanatomy of the joint. However, current treatment ignores AMD sustained by cartilage at the time of injury. We are exploring aggressive biomaterial-based interventions designed to treat the primary pathological components of AMD. This study describes the development of a novel injectable co-polymer solution that forms a gel at physiological temperatures that can be photocrosslinked, and can form a nanocomposite gel in situ through mineralization. The injectable co-polymer solution will allow the material to fill cracks in the cartilage after trauma. The mechanical properties of the nanocomposite are similar to those of native cartilage, as measured by compressive and shear testing. It thereby has the potential to mechanically stabilize and restore local structural integrity to acutely injured cartilage. Additionally, in situ mineralization ensures good adhesion between the biomaterial and cartilage at the interface, as measured through tensile and shear testing. Thus we have successfully developed a new injectable co-polymer which forms a nanocomposite in situ with mechanical properties similar to those of native cartilage, and which can bond well to native cartilage. This material has the potential to stabilize injured cartilage and prevent PTOA.
Details
- Title: Subtitle
- Synthesis of a novel photopolymerized nanocomposite hydrogel for treatment of acute mechanical damage to cartilage
- Creators
- Kathryn E Schlichting - Department of Materials Science and Engineering, Iowa State University, USATrishelle M Copeland-Johnson - Department of Chemical Engineering, University of South Florida, USAMatthew Goodman - Department of Materials Science and Engineering, Iowa State University, USARobert J Lipert - Institute for Combinatorial Discovery, Iowa State University, USATanya Prozorov - Division of Materials Sciences and Engineering, Ames Laboratory, USAXunpei Liu - Department of Chemical and Biological Engineering, Iowa State University, USATodd O McKinley - Department of Orthopaedic Surgery and Rehabilitation, University of Iowa, Ames, IA 50011, USAZhiqun Lin - Department of Materials Science and Engineering, Iowa State University, USAJames A Martin - Department of Orthopaedic Surgery and Rehabilitation, University of Iowa, Ames, IA 50011, USASurya K Mallapragada - Department of Materials Science and Engineering, Iowa State University, USA
- Resource Type
- Journal article
- Publication Details
- Acta biomaterialia, Vol.7(8), pp.3094-3100
- DOI
- 10.1016/j.actbio.2011.04.010
- PMID
- 21530694
- PMCID
- PMC4950507
- NLM abbreviation
- Acta Biomater
- ISSN
- 1742-7061
- eISSN
- 1878-7568
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Orthopedics and Rehabilitation
- Record Identifier
- 9984040006402771
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