Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus

I. O DONKOR; M. Lee SANDERS

doi:10.1016/S0960-894X(01)00524-8

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Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus

Journal article

Peer reviewed

Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus

I. O DONKOR and M. Lee SANDERS

Bioorganic & medicinal chemistry letters, Vol.11(19), pp.2647-2649

2001

DOI: 10.1016/S0960-894X(01)00524-8

PMID: 11551769

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https://doi.org/10.7270/q28k78cvView

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Abstract

The reported diketopiperazine calpain inhibitor, cis-L-L-3,6-bis-(4-hydroxybenzyl)-1,4-dimethylpiperazine-2,5-dione 1, and its analogues 3 and 4 were synthesized from the corresponding amino acids. The previously assigned structure of 1 is confirmed but neither synthetic 1 nor its N-methylphenylalanine analogues 3 and 4 inhibit porcine erythrocyte calpain I.

Fundamental and applied biological sciences. Psychology

Biological and medical sciences

Hydrolases

Analytical, structural and metabolic biochemistry

Enzymes and enzyme inhibitors

Details

Title: Subtitle: Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus
Creators: I. O DONKOR - Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, United States
M. Lee SANDERS - Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, United States
Resource Type: Journal article
Publication Details: Bioorganic & medicinal chemistry letters, Vol.11(19), pp.2647-2649
DOI: 10.1016/S0960-894X(01)00524-8
PMID: 11551769
NLM abbreviation: Bioorg Med Chem Lett
ISSN: 0960-894X
eISSN: 1464-3405
Publisher: Elsevier
Language: English
Date published: 2001
Academic Unit: Nephrology; Internal Medicine
Record Identifier: 9984094873702771

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