Journal article
Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling
Chemosphere (Oxford), Vol.45(8), pp.1119-1127
2001
DOI: 10.1016/S0045-6535(01)00052-2
PMID: 11695625
Abstract
An improved synthesis of hydroxylated polychlorinated biphenyls (PCBs) which are structurally related to the major hydroxy PCB congeners identified in human plasma is described. The coupling of (chlorinated) aryl boronic acids with bromochloro anisoles using the standard conditions of the Suzuki coupling gave the desired hydroxylated PCB metabolites in good to excellent yields. The approach offers the advantage of high selectivity and good yields compared to conventional methods such as the Cadogan reaction and allows the use of less toxic starting materials.
Details
- Title: Subtitle
- Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling
- Creators
- Hans-Joachim LehmlerLarry W Robertson
- Resource Type
- Journal article
- Publication Details
- Chemosphere (Oxford), Vol.45(8), pp.1119-1127
- DOI
- 10.1016/S0045-6535(01)00052-2
- PMID
- 11695625
- NLM abbreviation
- Chemosphere
- ISSN
- 0045-6535
- eISSN
- 1879-1298
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2001
- Academic Unit
- Occupational and Environmental Health; Iowa Neuroscience Institute
- Record Identifier
- 9984000918502771
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