Journal article
Synthesis of multivalent tuberculosis and Leishmania-associated capping carbohydrates reveals structure-dependent responses allowing immune evasion
Journal of the American Chemical Society, Vol.132(33), pp.11428-11430
08/25/2010
DOI: 10.1021/ja103351m
PMCID: PMC3816587
PMID: 20669964
Abstract
Mycobacterium tuberculosis and the protozoan parasites of the genus Leishmania are intracellular pathogens that can survive in macrophages--the very white blood cells of the immune system responsible for engulfing and ultimately clearing foreign invaders. The ability of these pathogens to hide within immune cells has made the design of effective therapies, including vaccines, to control tuberculosis and leishmaniasis particularly challenging. Herein we present the synthesis and development of carbohydrate-based probes to demonstrate that changes in pathogen-associated surface oligosaccharides are sufficient to alter cellular immune responses and thereby let a pathogen hide from immune surveillance.
Details
- Title: Subtitle
- Synthesis of multivalent tuberculosis and Leishmania-associated capping carbohydrates reveals structure-dependent responses allowing immune evasion
- Creators
- Eun-Ho Song - Department of Chemistry and The Plant Science Institute, Gilman Hall, Iowa State University, Ames, Iowa 50011-3111, USAAlex O OsanyaChristine A PetersenNicola L B Pohl
- Resource Type
- Journal article
- Publication Details
- Journal of the American Chemical Society, Vol.132(33), pp.11428-11430
- DOI
- 10.1021/ja103351m
- PMID
- 20669964
- PMCID
- PMC3816587
- NLM abbreviation
- J Am Chem Soc
- ISSN
- 0002-7863
- eISSN
- 1520-5126
- Publisher
- United States
- Grant note
- R21 AI074711 / NIAID NIH HHS 1 R21 AI074711-01A2 / NIAID NIH HHS
- Language
- English
- Date published
- 08/25/2010
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983995154302771
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