Journal article
Synthesis of nucleoside α-hydroxy phosphonates
Tetrahedron letters, Vol.34(37), pp.5843-5846
1993
DOI: 10.1016/S0040-4039(00)73794-4
Abstract
Nucleophilic addition of a dialkyl phosphite anion to 2′- or 3′-keto nucleosides results in an efficient synthesis of 2′-hydroxy-2′-phosphono- or 3′-hydroxy-3′-phosphononucleosides. The stereochemistry of one such adduct, 5′-O-trityl-3′-β-hydroxy-3′-α-(diethyl)phosphonothymidine, was determined by single crystal diffraction analysis. Nucleophilic addition of diethyl phosphite anion to 2′- or 3′-keto nucleosides results in an efficient synthesis of 2′-β-hydroxy-2′-α-phosphono-or 3′-β-hydroxy-3′-α-phosphononucleosides. The stereochemistry of one such adduct, 5′-O-trityl-3′-β-hydroxy-3′-α-phosphonothymidine, was determined by single crystal diffraction analysis.
Details
- Title: Subtitle
- Synthesis of nucleoside α-hydroxy phosphonates
- Creators
- Wenkui Lan McEldoonKoo LeeDavid F Wiemer
- Resource Type
- Journal article
- Publication Details
- Tetrahedron letters, Vol.34(37), pp.5843-5846
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0040-4039(00)73794-4
- ISSN
- 0040-4039
- eISSN
- 1873-3581
- Language
- English
- Date published
- 1993
- Academic Unit
- Chemistry; Neuroscience and Pharmacology
- Record Identifier
- 9983985825002771
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