Journal article
Synthesis of radiofluorinated analogs of m-tyrosine as potential l-dopa tracers via direct reaction with acetylhypofluorite
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, Vol.41(5), pp.433-437
1990
DOI: 10.1016/0883-2889(90)90001-W
PMID: 2166010
Abstract
The direct electrophilic radiofluorination of
m-tyrosine using [
18F]acetylhypofluorite was investigated. Results showed that this reaction was both rapid and efficient with recovered decay corrected yield of 71% radiofluorinated
m-tyrosines based on starting [
18F]acetylhypofluorite. Specific activity of the product obtained in this study was 100–200 mCi/mmol although 1–5 Ci/mmol are easily achievable with our improved production of [
18F]AcOF. Three positional isomers were found and identified by
19F-NMR to be 2-, 4-, 6-fluoro-
m-tyrosine with a distribution of 36:11:52, respectively. This measured distribution allowed the assignment of the radio-HPLC peaks. Biological studies are currently underway in our laboratory using these fluoro-
m-tyrosines to determine which isomer would be most suited for the evaluation of the dopamine system by positron tomography.
Details
- Title: Subtitle
- Synthesis of radiofluorinated analogs of m-tyrosine as potential l-dopa tracers via direct reaction with acetylhypofluorite
- Creators
- Onofre T DeJesus - Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53706, U.S.AJohn J Sunderland - Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53706, U.S.AJ.Robert Nickles - Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53706, U.S.AJogeshwar Mukherjee - UC-FMI PET Center, University of Chicago, Chicago, IL 60637, U.S.AEvan H Appelman - Chemistry Division, Argonne National Laboratory, Argonne, IL 60439, U.S.A
- Resource Type
- Journal article
- Publication Details
- International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, Vol.41(5), pp.433-437
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0883-2889(90)90001-W
- PMID
- 2166010
- ISSN
- 0883-2889
- eISSN
- 1872-9800
- Language
- English
- Date published
- 1990
- Academic Unit
- Radiology; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984047711902771
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