Journal article
Synthesis of the cis-fused hexahydroxanthene system via cationic cascade cyclization
Tetrahedron letters, Vol.50(27), pp.3881-3884
2009
DOI: 10.1016/j.tetlet.2009.04.052
Abstract
The cis-fused hexahydroxanthene system can be obtained through a cascade cyclization initiated by Lewis acid-mediated epoxide opening and terminated by reaction with a MOM-protected phenol. Only a single diastereomer of the product was obtained with stereochemistry verified by diffraction analysis. This demonstrates the viability of this approach to natural products containing the cis-fused hexahydroxanthene skeleton, and supports preparation of more complex targets through a similar strategy.
Details
- Title: Subtitle
- Synthesis of the cis-fused hexahydroxanthene system via cationic cascade cyclization
- Creators
- Jeffrey D NeighborsJoseph J TopczewskiDale C SwensonDavid F Wiemer
- Resource Type
- Journal article
- Publication Details
- Tetrahedron letters, Vol.50(27), pp.3881-3884
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.tetlet.2009.04.052
- ISSN
- 0040-4039
- eISSN
- 1873-3581
- Language
- English
- Date published
- 2009
- Academic Unit
- Chemistry; Neuroscience and Pharmacology
- Record Identifier
- 9983986097102771
Metrics
21 Record Views