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Synthetic studies toward the construction of the cis-decalin portion of superstolides A and B. Application of a sequential double michael reaction and an anionic oxy-Cope rearrangement
Journal article   Peer reviewed

Synthetic studies toward the construction of the cis-decalin portion of superstolides A and B. Application of a sequential double michael reaction and an anionic oxy-Cope rearrangement

Zhengmao Hua, Wensheng Yu, Mei Su and Zhendong Jin
Organic letters, Vol.7(10), pp.1939-1942
05/12/2005
DOI: 10.1021/ol050339w
PMID: 15876024

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Abstract

A highly convergent strategy for the asymmetric synthesis of the cis-decalin portion of the antitumor macrolide superstolide A was developed. The key reactions in our approach involve a sequential double Michael reaction and an anionic oxy-Cope rearrangement.
Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Candida - enzymology Hydrolysis Macrolides - chemical synthesis Macrolides - chemistry Molecular Structure Porifera - chemistry Stereoisomerism Tetrahydronaphthalenes - chemical synthesis Tetrahydronaphthalenes - chemistry

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