Journal article
System for Informatics in the Molecular Pathology Laboratory
The Journal of molecular diagnostics : JMD, Vol.20(4), pp.522-532
07/2018
DOI: 10.1016/j.jmoldx.2018.03.008
Abstract
Next-generation sequencing (NGS) diagnostic assays increasingly are becoming the standard of care in oncology practice. As the scale of an NGS laboratory grows, management of these assays requires organizing large amounts of information, including patient data, laboratory processes, genomic data, as well as variant interpretation and reporting. Although several Laboratory Information Systems and/or Laboratory Information Management Systems are commercially available, they may not meet all of the needs of a given laboratory, in addition to being frequently cost-prohibitive. Herein, we present the System for Informatics in the Molecular Pathology Laboratory (SIMPL), a free and open-source Laboratory Information System/Laboratory Information Management System for academic and nonprofit molecular pathology NGS laboratories, developed at the Genomic and Molecular Pathology Division at the University of Chicago Medicine. SIMPL was designed as a modular end-to-end information system to handle all stages of the NGS laboratory workload from test order to reporting. We describe the features of SIMPL, its clinical validation at University of Chicago Medicine, and its installation and testing within a different academic center laboratory (University of Colorado), and we propose a platform for future community co-development and interlaboratory data sharing.
Details
- Title: Subtitle
- System for Informatics in the Molecular Pathology Laboratory
- Creators
- Wenjun Kang - University of ChicagoSabah Kadri - University of ChicagoRutika Puranik - University of ChicagoMichelle N. Wurst - University of ChicagoSushant A. Patil - University of ChicagoIbro Mujacic - University of ChicagoSonia Benhamed - University of ChicagoNifang Niu - University of ChicagoChao Jie Zhen - University of ChicagoBekim Ameti - University of ChicagoBradley C. Long - University of ChicagoFilipo Galbo - University of ChicagoDavid Montes - University of ChicagoCrystal Iracheta - University of ChicagoVenessa L. Gamboa - University of ChicagoDaisy Lopez - University of ChicagoMichael Yourshaw - University of Colorado Anschutz Medical CampusCarolyn A. Lawrence - University of Colorado Anschutz Medical CampusDara L. Aisner - University of Colorado Anschutz Medical CampusCarrie Fitzpatrick - University of ChicagoMegan E. McNerney - University of ChicagoY. Lynn Wang - University of ChicagoJorge Andrade - University of ChicagoSamuel L. Volchenboum - University of ChicagoLarissa V. Furtado - University of ChicagoLauren L. Ritterhouse - University of ChicagoJeremy P. Segal - University of Chicago
- Resource Type
- Journal article
- Publication Details
- The Journal of molecular diagnostics : JMD, Vol.20(4), pp.522-532
- Publisher
- Elsevier Inc; NEW YORK
- DOI
- 10.1016/j.jmoldx.2018.03.008
- ISSN
- 1525-1578
- eISSN
- 1943-7811
- Number of pages
- 11
- Grant note
- UL1 TR000430 / NIH Clinical and Translational Science Awards grant (https://doi.org/10.13039/100000002)
- Language
- English
- Date published
- 07/2018
- Academic Unit
- Stead Family Department of Pediatrics; Medical Genetics and Genomics
- Record Identifier
- 9984701550902771
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