Journal article
Systematic Review and Meta-analysis of Histological Gastric Biopsy Aspects According to the Updated Sydney System in Children
Journal of pediatric gastroenterology and nutrition, Vol.74(1), pp.13-19
01/01/2022
DOI: 10.1097/MPG.0000000000003259
Abstract
Objectives: A descriptive and comparative study of gastric histological aspects according to the updated Sydney classification (USC), obtained from Helicobacter pylori-positive versus H pylori-negative children referred for upper gastrointestinal endoscopy. Methods: The Prisma method was used to perform a systematic review and meta-analysis. Selection criteria were based on following key words USC, H pylori, children, endoscopy, or biopsy. Publication biases were assessed according to the Newcastle-Ottawa Scale, and a meta-regression analysis was done. The study was registered on the PROSPERO platform. Results: Between 1994 and 2017, 1238 references were found; 97 studies were retained for the systematic review with a total number of 25,867 children; 75 studies were selected for the meta-analysis concerning 5990 H pylori-infected and 17,782 uninfected children.H pylori-positive versus H pylori-negative children, according to the USC, showed significantly higher relative risk for gastric antral and corpus chronic inflammation, presence of neutrophils, and of lymphoid follicles, and gastric mucosa atrophy, whereas, intestinal metaplasia showed a significantly higher RR only in antral biopsies. The meta-regression analysis showed that H pylori-positive versus H pylori-negative children had significantly higher risk only for corpus activity according to age, recurrent abdominal pain, and geographical area of low H pylori prevalence. Conclusions: H pylori infection in children was associated with higher relative risk for gastric antral and corpus chronic inflammation, presence of neutrophils, lymphoid follicles, and rare gastric mucosa atrophy, whereas, rare intestinal metaplasia was only significantly higher in the antral area.
Details
- Title: Subtitle
- Systematic Review and Meta-analysis of Histological Gastric Biopsy Aspects According to the Updated Sydney System in Children
- Creators
- Nicolas Kalach - Groupe Hospitalier de l'Institut Catholique de LilleMisak Zrinjka - Children's Hospital ZagrebPatrick Bontems - Université Libre de BruxellesMichal Kori - Kaplan Medical CenterMatjaz Homan - Ljubljana University Medical CentreJose Cabral - Hospital de Dona EstefâniaThomas Casswall - Karolinska University HospitalSonny Chong - St Helier HospitalMaria Luz Cilleruelo - Hospital Universitario Puerta de Hierro MajadahondaSimona Faraci - Bambino Gesù Children's HospitalFrancis Megraud - Université de BordeauxAlexandra Papadopoulou - National and Kapodistrian University of AthensEnder Pehlivanoglu - Istanbul Kent UniversityJosette Raymond - Université Paris CitéFrancesca Rea - Bambino Gesù Children's HospitalRogalidou Maria - National and Kapodistrian University of AthensEleftheria Roma - Mitera HospitalMarta Tavares - Centro Hospitalar do PortoMeltem Ugras - Yeditepe UniversityVaidotas Urbonas - Vilnius UniversityPedro Urruzuno - Hospital Universitario 12 De OctubrePierre Gosset - Université de LilleColette Creusy - Université de LilleMathilde Delebarre - Université de LilleStephane Verdun - Groupe Hospitalier de l'Institut Catholique de LilleESPGHAN-Helicobacter Pylori
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric gastroenterology and nutrition, Vol.74(1), pp.13-19
- DOI
- 10.1097/MPG.0000000000003259
- ISSN
- 0277-2116
- eISSN
- 1536-4801
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Grant note
- BioMerieux Allergan; AbbVie Mobidiag
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9985214102502771
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