Journal article
Systematic review on the known variants and genes associated with orofacial clefts in Africa
PAMJ Clinical Medicine, Vol.9, 46
2022
DOI: 10.11604/pamj-cm.2022.9.46.31756
Abstract
A systematic review of the literature was conducted to assess the known variants and genes associated with orofacial clefts (OFC) in Africa. This was performed via an electronic search, using a set of predefined search terms, in seven databases (PubMed, EBSCOhost, ScienceDirect, Web of Science, Google Scholar, OpenGrey and WorldCat) from 2000-2020. Full text articles concerning the genetic aetiology of OFC in Africa were included. Articles were filtered using the PICO eligibility criteria and data extraction followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The primary search yielded 489 citations, of which 16 studies were finally analyzed. We identified 61 genetic variants across the 16 studies, and 35 were novel variants. Interferon Regulatory Factor 6 (IRF6) was the most common gene investigated. In most studies, the genetic testing was not performed in Africa. There is a wealth of information to be learnt from interrogating the African genome as we try to understand the role of variants in health and diseases. The protocol for this systematic review is registered in the international prospective register of systematic reviews
Details
- Title: Subtitle
- Systematic review on the known variants and genes associated with orofacial clefts in Africa
- Creators
- Thirona NaickerAzeez AladeWaheed AwotoyeHelen MalherbeColleen AldousAzeez Butali
- Resource Type
- Journal article
- Publication Details
- PAMJ Clinical Medicine, Vol.9, 46
- DOI
- 10.11604/pamj-cm.2022.9.46.31756
- ISSN
- 2707-2797
- eISSN
- 2707-2797
- Language
- English
- Date published
- 2022
- Academic Unit
- Oral Pathology, Radiology and Medicine; Stead Family Department of Pediatrics; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984356560202771
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