Journal article
Systemic Bevacizumab for Treatment of Respiratory Papillomatosis: International Consensus Statement
The Laryngoscope, Vol.131(6), pp.E1941-E1949
06/2021
DOI: 10.1002/lary.29343
PMCID: PMC9034687
PMID: 33405268
Abstract
The purpose of this study is to develop consensus on key points that would support the use of systemic bevacizumab for the treatment of recurrent respiratory papillomatosis (RRP), and to provide preliminary guidance surrounding the use of this treatment modality.
Delphi method-based survey series.
A multidisciplinary, multi-institutional panel of physicians with experience using systemic bevacizumab for the treatment of RRP was established. The Delphi method was used to identify and obtain consensus on characteristics associated with systemic bevacizumab use across five domains: 1) patient characteristics; 2) disease characteristics; 3) treating center characteristics; 4) prior treatment characteristics; and 5) prior work-up.
The international panel was composed of 70 experts from 12 countries, representing pediatric and adult otolaryngology, hematology/oncology, infectious diseases, pediatric surgery, family medicine, and epidemiology. A total of 189 items were identified, of which consensus was achieved on Patient Characteristics (9), Disease Characteristics (10), Treatment Center Characteristics (22), and Prior Workup Characteristics (18).
This consensus statement provides a useful starting point for clinicians and centers hoping to offer systemic bevacizumab for RRP and may serve as a framework to assess the components of practices and centers currently using this therapy. We hope to provide a strategy to offer the treatment and also to provide a springboard for bevacizumab's use in combination with other RRP treatment protocols. Standardized delivery systems may facilitate research efforts and provide dosing regimens to help shape best-practice applications of systemic bevacizumab for patients with early-onset or less-severe disease phenotypes.
5 Laryngoscope, 131:E1941-E1949, 2021.
Details
- Title: Subtitle
- Systemic Bevacizumab for Treatment of Respiratory Papillomatosis: International Consensus Statement
- Creators
- Douglas R Sidell - Stanford UniversityKarthik Balakrishnan - Stanford UniversitySimon R Best - Johns Hopkins UniversityKaren Zur - University of PennsylvaniaJulia Buckingham - Stanford UniversityAlessandro De Alarcon - University of CincinnatiFuad M Baroody - University of ChicagoJonathan M Bock - Medical College of WisconsinEmily F Boss - Johns Hopkins UniversityCharles M Bower - University of Arkansas for Medical SciencesPaolo Campisi - University of TorontoSharon F Chen - Lucile Packard Children's HospitalJeffrey M Clarke - Duke UniversityKevin D Clarke - University of British ColumbiaAlejandro Cocciaglia - Boston Children's HospitalRobin T Cotton - University of CincinnatiGiselle Cuestas - Respiratory Endoscopy Section, ENT Department, Hospital General de Niños "Dr. Pedro de Elizalde", Buenos Aires, ArgentinaKara L Davis - Stanford UniversityVictor H DeFago - Pediatric Surgery, Sanatorio del Salvador Privado SA, Cordoba, ArgentinaFrederik G Dikkers - University of AmsterdamInes Dossans - Otolaryngology-Head and Neck Surgery, Hospital Pereira Rossell, Montevideo, UruguayWalter Florez - Instituto Nacional de Salud del NiñoElizabeth Fox - St. Jude Children's Research HospitalAaron D Friedman - University of CincinnatiNazaneen Grant - Georgetown UniversityOsama Hamdi - Howard UniversityNorman D Hogikyan - University of MichiganKaalan Johnson - University of WashingtonLiane B Johnson - Dalhousie UniversityRomaine F Johnson - The University of Texas Southwestern Medical CenterPeggy Kelly - Boston Children's HospitalAdam M Klein - Emory UniversityClaire M Lawlor - George Washington UniversityNicolas Leboulanger - Université Paris CitéAlejandro G Levy - Orlando Regional Medical CenterDerek Lam - Oregon Health & Science UniversityGreg R Licameli - Harvard UniversitySteve Long - Kaiser PermanenteDavid G Lott - Mayo Clinic in FloridaDayse Manrique - Universidade Federal de São PauloJames Scott McMurray - University of Wisconsin–MadisonKara D Meister - Stanford UniversityAnna H Messner - Baylor College of MedicineMichael Mohr - University of MünsterPamela Mudd - George Washington UniversityAnthony J Mortelliti - SUNY Upstate Medical UniversityDaniel Novakovic - The University of SydneyJulina Ongkasuwan - Baylor College of MedicineShazia Peer - University of Cape TownKrysztof Piersiala - Karolinska InstitutetJeremy D Prager - Boston Children's HospitalSeth M Pransky - Boston Children's HospitalDiego Preciado - George Washington UniversityTiffany Raynor - Baylor College of MedicineRico N P M Rinkel - Vrije Universiteit AmsterdamHugo Rodriguez - Respiratory Endoscopy Department, Hospital de Pediatria Prof Dr. Juan P. Garrahan, Buenos Aires, ArgentinaVerónica P Rodríguez - Respiratory Endoscopy Section, ENT Department, Hospital General de Niños "Dr. Pedro de Elizalde", Buenos Aires, ArgentinaJohn Russell - Department of Paediatric Otolaryngology, Children's Health Ireland, Dublin, IrelandMaría Laura Scatolini - Respiratory Endoscopy Department, Hospital de Pediatria Prof Dr. Juan P. Garrahan, Buenos Aires, ArgentinaPatrick Scheffler - Stanford UniversityDavid F Smith - University of CincinnatiLee P Smith - Hofstra UniversityMarshall E Smith - University of UtahRichard J H Smith - University of IowaAbraham Sorom - Otolaryngology, Head and Neck Surgery, Confluence Health, Wenatchee, Washington, District of Columbia, U.S.AAmalia Steinberg - Alaska Native Medical CenterJohn A Stith - Washington University in St. LouisDana Thompson - Northwestern UniversityJerome W Thompson - Department of Otolaryngology-Head and Neck Surgery, Division of Pediatric ENT, LeBonheur Children's Hospital, College of Medicine, University of Tennnessee, Memphis, Tennessee, U.S.APatricio Varela - University of ChileDavid R White - Medical University of South CarolinaAndre M Wineland - Johns Hopkins UniversityChristina J Yang - Yeshiva UniversityCarlton J Zdanski - University of North Carolina at Chapel HillCraig S Derkay - Eastern Virginia Medical School
- Resource Type
- Journal article
- Publication Details
- The Laryngoscope, Vol.131(6), pp.E1941-E1949
- DOI
- 10.1002/lary.29343
- PMID
- 33405268
- PMCID
- PMC9034687
- NLM abbreviation
- Laryngoscope
- ISSN
- 0023-852X
- eISSN
- 1531-4995
- Grant note
- K08 HL148551 / NHLBI NIH HHS
- Language
- English
- Date published
- 06/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984256837702771
Metrics
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