Systemic Inflammatory Response Index and Futile Recanalization in Patients with Ischemic Stroke Undergoing Endovascular Treatment

Simona Lattanzi; Davide Norata; Afshin A. Divani; Mario Di Napoli; Serena Broggi; Chiara Rocchi; Santiago Ortega-Gutierrez; Gelsomina Mansueto; Mauro Silvestrini

doi:10.3390/brainsci11091164

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Systemic Inflammatory Response Index and Futile Recanalization in Patients with Ischemic Stroke Undergoing Endovascular Treatment

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Systemic Inflammatory Response Index and Futile Recanalization in Patients with Ischemic Stroke Undergoing Endovascular Treatment

Simona Lattanzi, Davide Norata, Afshin A. Divani, Mario Di Napoli, Serena Broggi, Chiara Rocchi, Santiago Ortega-Gutierrez, Gelsomina Mansueto and Mauro Silvestrini

Brain sciences, Vol.11(9), p.1164

09/01/2021

DOI: 10.3390/brainsci11091164

PMCID: PMC8468021

PMID: 34573185

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Abstract

Futile recanalization remains a significant challenge for endovascular treatment (EVT) of acute ischemic stroke (AIS). The inflammatory response that occurs after cerebral infarct plays a central role in stroke pathobiology that can influence the outcome of a recanalization procedure. The aim of this study was to evaluate the relationship between the systemic inflammatory response index (SIRI) and futile recanalization in patients with AIS. We retrospectively identified consecutive patients with ischemic stroke due to proximal arterial occlusion in the anterior circulation, who were treated with EVT and achieved near-complete or complete recanalization. Absolute neutrophil count (ANC), absolute monocyte count (AMC), and absolute lymphocyte count (ALC) were collected from admission blood work to calculate SIRI as ANC x AMC/ALC. The study outcome was futile recanalization, defined as poor functional status [modified Rankin scale (mRS) score >= 3] at 3 months despite complete or near-complete recanalization. A total of 184 patients were included. Futile recanalization was observed in 110 (59.8%) patients. Older patients (odds ratio (OR) = 1.07, 95% confidence interval (CI): 1.04-1.10, p < 0.001), higher admission National Institutes of Health stroke scale score (OR = 1.10, 95% CI: 1.02-1.19, p = 0.013), and higher admission SIRI (OR = 1.08, 95% CI: 1.01-1.17, p = 0.028) increased the risk of the poor outcome at 3 months despite complete or near-complete recanalization.

Life Sciences & Biomedicine

Neurosciences

Neurosciences & Neurology

Science & Technology

Details

Title: Subtitle: Systemic Inflammatory Response Index and Futile Recanalization in Patients with Ischemic Stroke Undergoing Endovascular Treatment
Creators: Simona Lattanzi - Marche Polytechnic University
Davide Norata - Marche Polytechnic University
Afshin A. Divani - University of New Mexico
Mario Di Napoli - Neurological Service, SS Annunziata Hospital, Sulmona, 67039 L'Aquila, Italy.
Serena Broggi - Marche Polytechnic University
Chiara Rocchi - Marche Polytechnic University
Santiago Ortega-Gutierrez - University of Iowa
Gelsomina Mansueto - University of Campania "Luigi Vanvitelli"
Mauro Silvestrini - Marche Polytechnic University
Resource Type: Journal article
Publication Details: Brain sciences, Vol.11(9), p.1164
DOI: 10.3390/brainsci11091164
PMID: 34573185
PMCID: PMC8468021
NLM abbreviation: Brain Sci
ISSN: 2076-3425
eISSN: 2076-3425
Publisher: Mdpi
Number of pages: 9
Language: English
Date published: 09/01/2021
Academic Unit: Neurology; Radiology; Neurosurgery
Record Identifier: 9984302202002771

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