Journal article
Systemic Inflammatory Response Index and Futile Recanalization in Patients with Ischemic Stroke Undergoing Endovascular Treatment
Brain sciences, Vol.11(9), p.1164
09/01/2021
DOI: 10.3390/brainsci11091164
PMCID: PMC8468021
PMID: 34573185
Abstract
Futile recanalization remains a significant challenge for endovascular treatment (EVT) of acute ischemic stroke (AIS). The inflammatory response that occurs after cerebral infarct plays a central role in stroke pathobiology that can influence the outcome of a recanalization procedure. The aim of this study was to evaluate the relationship between the systemic inflammatory response index (SIRI) and futile recanalization in patients with AIS. We retrospectively identified consecutive patients with ischemic stroke due to proximal arterial occlusion in the anterior circulation, who were treated with EVT and achieved near-complete or complete recanalization. Absolute neutrophil count (ANC), absolute monocyte count (AMC), and absolute lymphocyte count (ALC) were collected from admission blood work to calculate SIRI as ANC x AMC/ALC. The study outcome was futile recanalization, defined as poor functional status [modified Rankin scale (mRS) score >= 3] at 3 months despite complete or near-complete recanalization. A total of 184 patients were included. Futile recanalization was observed in 110 (59.8%) patients. Older patients (odds ratio (OR) = 1.07, 95% confidence interval (CI): 1.04-1.10, p < 0.001), higher admission National Institutes of Health stroke scale score (OR = 1.10, 95% CI: 1.02-1.19, p = 0.013), and higher admission SIRI (OR = 1.08, 95% CI: 1.01-1.17, p = 0.028) increased the risk of the poor outcome at 3 months despite complete or near-complete recanalization.
Details
- Title: Subtitle
- Systemic Inflammatory Response Index and Futile Recanalization in Patients with Ischemic Stroke Undergoing Endovascular Treatment
- Creators
- Simona Lattanzi - Marche Polytechnic UniversityDavide Norata - Marche Polytechnic UniversityAfshin A. Divani - University of New MexicoMario Di Napoli - Neurological Service, SS Annunziata Hospital, Sulmona, 67039 L'Aquila, Italy.Serena Broggi - Marche Polytechnic UniversityChiara Rocchi - Marche Polytechnic UniversitySantiago Ortega-Gutierrez - University of IowaGelsomina Mansueto - University of Campania "Luigi Vanvitelli"Mauro Silvestrini - Marche Polytechnic University
- Resource Type
- Journal article
- Publication Details
- Brain sciences, Vol.11(9), p.1164
- Publisher
- Mdpi
- DOI
- 10.3390/brainsci11091164
- PMID
- 34573185
- PMCID
- PMC8468021
- ISSN
- 2076-3425
- eISSN
- 2076-3425
- Number of pages
- 9
- Language
- English
- Date published
- 09/01/2021
- Academic Unit
- Neurology; Radiology; Neurosurgery
- Record Identifier
- 9984302202002771
Metrics
15 Record Views