Systemic and localized extra-central nervous system bacterial infections and the risk of dementia among US veterans: A retrospective cohort study

Francis Mawanda; Robert B Wallace; Kimberly McCoy; Thad E Abrams

doi:10.1016/j.dadm.2016.08.004

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Systemic and localized extra-central nervous system bacterial infections and the risk of dementia among US veterans: A retrospective cohort study

Journal article

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Systemic and localized extra-central nervous system bacterial infections and the risk of dementia among US veterans: A retrospective cohort study

Francis Mawanda, Robert B Wallace, Kimberly McCoy and Thad E Abrams

Alzheimer's & dementia : diagnosis, assessment & disease monitoring, Vol.4(1), pp.109-117

2016

DOI: 10.1016/j.dadm.2016.08.004

PMCID: PMC5061465

PMID: 27752534

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Abstract

Emerging evidence indicates associations between extra-central nervous system (CNS) bacterial infections and an increased risk for dementia; however, epidemiological evidence is still very limited. This study involved a retrospective cohort of a national sample of US veterans (N = 417,172) aged ≥56 years. Extended Cox proportional hazard models adjusted for demographic characteristics and medical and psychiatric comorbidities determined the associations between systemic and localized extra-CNS bacterial infections occurring >2 years before the initial dementia diagnosis and the risk for dementia. Exposure to any extra-CNS bacterial infection was associated with a significantly increased risk for dementia (hazard ratio [HR] = 1.20 [95% confidence interval = 1.16–1.24]). Independently, septicemia (HR = 1.39 [1.16–1.66]), bacteremia (HR = 1.22 [1.00–1.49]), osteomyelitis (HR = 1.20 [1.06–1.37]), pneumonia (HR = 1.10 [1.02–1.19]), urinary tract infections (HR = 1.13 [1.08–1.18]), and cellulitis (HR = 1.14 [1.09–1.20]) were associated with a significantly increased risk for dementia. Both systemic and localized extra-CNS bacterial infections are associated with an increased risk for developing dementia.

Osteomyelitis

Pneumonia

Bacterial infections

Septicemia

Veterans

Urinary tract infections

Cellulitis

Bacteremia

Dementia

Details

Title: Subtitle: Systemic and localized extra-central nervous system bacterial infections and the risk of dementia among US veterans: A retrospective cohort study
Creators: Francis Mawanda - Department of Epidemiology, University of Iowa, Iowa City, IA, USA
Robert B Wallace - Department of Epidemiology, University of Iowa, Iowa City, IA, USA
Kimberly McCoy - Center for Comprehensive Access & Delivery Research and Evaluation, Iowa City VA Health Care System, Iowa City, IA, USA
Thad E Abrams - Department of Epidemiology, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Alzheimer's & dementia : diagnosis, assessment & disease monitoring, Vol.4(1), pp.109-117
DOI: 10.1016/j.dadm.2016.08.004
PMID: 27752534
PMCID: PMC5061465
NLM abbreviation: Alzheimers Dement (Amst)
ISSN: 2352-8729
eISSN: 2352-8729
Publisher: Elsevier Inc
Language: English
Date published: 2016
Academic Unit: Psychiatry; Epidemiology; Injury Prevention Research Center; General Internal Medicine; Internal Medicine
Record Identifier: 9984094374802771

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