Systemic angiotensin II, blood pressure and supraoptic neuronal activity

L.D Mitchell; M.F Callahan; L.D Wilkin; S.I Bellin; A.K Johnson

doi:10.1016/0196-9781(85)90025-7

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Systemic angiotensin II, blood pressure and supraoptic neuronal activity

Journal article

Peer reviewed

Systemic angiotensin II, blood pressure and supraoptic neuronal activity

L.D Mitchell, M.F Callahan, L.D Wilkin, S.I Bellin and A.K Johnson

Peptides (New York, N.Y. : 1980), Vol.6(1), pp.153-158

1985

DOI: 10.1016/0196-9781(85)90025-7

PMID: 4047978

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Abstract

Recordings of SON single unit activity and systemic arterial blood pressure (B.P.) were taken from 10 rats while systemic infusions of angiotensin II (AII), 1–1000 ng/kg body weight/min in 7 steps, or phenylephrine, 1–100 ng in 3 steps were administered. The relationship between AII concentrations and neuronal activity was biphasic. Within the physiological range (1 ng to 100 ng) AII excited single units in a dose dependent manner, but it had little effect on B.P. At higher concentrations, B.P. rose and neuronal activity was decreased. Phenylephrine, however, did not excite neuronal activity. With increasing phenylephrine concentrations, B.P. rose and neuronal activity slowed. We conclude that increased B.P. may dampen the SON neuronal output by baroreceptor inhibition. Under physiological conditions, therefore, AII may serve to reinforce tonic vasopressin release while inhibiting vasopressin release at pressor doses. This further suggests a role for plasma AII as an important link of the renal-hypothalamic-hormonal feedback loop.

Angiotensin

Blood pressure

Fluid regulation

Supraoptic nucleus

Vasopressin

Details

Title: Subtitle: Systemic angiotensin II, blood pressure and supraoptic neuronal activity
Creators: L.D Mitchell - Department of Psychology, University of Iowa, Iowa City, IA 52242 USA
M.F Callahan - Department of Psychology, University of Iowa, Iowa City, IA 52242 USA
L.D Wilkin - Department of Anatomy, University of Iowa, Iowa City, IA 52242 USA
S.I Bellin - Department of Psychology, University of Iowa, Iowa City, IA 52242 USA
A.K Johnson - Department of Psychology, University of Iowa, Iowa City, IA 52242 USA
Resource Type: Journal article
Publication Details: Peptides (New York, N.Y. : 1980), Vol.6(1), pp.153-158
DOI: 10.1016/0196-9781(85)90025-7
PMID: 4047978
NLM abbreviation: Peptides
ISSN: 0196-9781
eISSN: 1873-5169
Publisher: Elsevier Inc
Language: English
Date published: 1985
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984213423902771

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