Journal article
Systemic plasma levels of nitrite/nitrate (NOx) reflect brachial flow-mediated dilation responses in young men and women
Clinical and experimental pharmacology & physiology, Vol.34(12), pp.1291-1293
12/2007
DOI: 10.1111/j.1440-1681.2007.04715.x
PMID: 17973870
Abstract
1. The aim of the present study was to determine the relationship between plasma levels of nitrite/nitrite (NO(x)) and brachial flow-mediated dilation (FMD) in healthy young men and women. 2. Brachial artery FMD was assessed non-invasively using high-resolution ultrasound in 36 young men and women (21 +/- 3 years; 18 men and 18 women). Blood samples for NO(x) assays were collected from an indwelling venous catheter in the forearm following an overnight fast and a 36 h low-nitrate diet. 3. Plasma levels of NO(x) were related to peak brachial FMD% (r = 0.53; P = 0.001). The relationship was maintained when the brachial dilation was expressed as absolute diameter change (Deltamm; r = 0.51; P = 0.002) and when it was normalized (/s) to the mean shear rate (r = 0.50; P = 0.002). 4. The present study demonstrates a relationship between peak FMD in the brachial artery and plasma levels of NO(x) in young men and women. This relationship suggests that brachial FMD and/or plasma NO(x) may be used as markers of peripheral endothelial function.
Details
- Title: Subtitle
- Systemic plasma levels of nitrite/nitrate (NOx) reflect brachial flow-mediated dilation responses in young men and women
- Creators
- Darren P Casey - Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL 32611, USA. dcasey@hhp.ufl.eduDarren T BeckRandy W Braith
- Resource Type
- Journal article
- Publication Details
- Clinical and experimental pharmacology & physiology, Vol.34(12), pp.1291-1293
- Publisher
- Australia
- DOI
- 10.1111/j.1440-1681.2007.04715.x
- PMID
- 17973870
- ISSN
- 0305-1870
- eISSN
- 1440-1681
- Language
- English
- Date published
- 12/2007
- Academic Unit
- Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984047986902771
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