Systems Approach to Understanding Electromechanical Activity in the Human Heart : A National Heart, Lung, and Blood Institute Workshop Summary

Yoram RUDY; Michael J ACKERMAN; Natalia A TRAYANOVA; David R VAN WAGONER; Andras VARRO; James N WEISS; David A LATHROP; Donald M BERS; Colleen E CLANCY; Steven R HOUSER; Barry LONDON; Andrew D MCCULLOCH; Dennis A PRZYWARA; Randall L RASMUSSON; R. John SOLARO

doi:10.1161/CIRCULATIONAHA.108.772715

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Systems Approach to Understanding Electromechanical Activity in the Human Heart : A National Heart, Lung, and Blood Institute Workshop Summary

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Systems Approach to Understanding Electromechanical Activity in the Human Heart : A National Heart, Lung, and Blood Institute Workshop Summary

Yoram RUDY, Michael J ACKERMAN, Natalia A TRAYANOVA, David R VAN WAGONER, Andras VARRO, James N WEISS, David A LATHROP, Donald M BERS, Colleen E CLANCY, Steven R HOUSER, …

Circulation (New York, N.Y.), Vol.118(11), pp.1202-1211

2008

DOI: 10.1161/CIRCULATIONAHA.108.772715

PMCID: PMC2908516

PMID: 18779456

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Abstract

The National Heart, Lung, and Blood Institute (NHLBI) convened a workshop of cardiologists, cardiac electrophysiologists, cell biophysicists, and computational modelers on August 20 and 21, 2007, in Washington, DC, to advise the NHLBI on new research directions needed to develop integrative approaches to elucidate human cardiac function. The workshop strove to identify limitations in the use of data from nonhuman animal species for elucidation of human electromechanical function/activity and to identify what specific information on ion channel kinetics, calcium handling, and dynamic changes in the intracellular/extracellular milieu is needed from human cardiac tissues to develop more robust computational models of human cardiac electromechanical activity. This article summarizes the workshop discussions and recommendations on the following topics: (1) limitations of animal models and differences from human electrophysiology, (2) modeling ion channel structure/function in the context of whole-cell electrophysiology, (3) excitation-contraction coupling and regulatory pathways, (4) whole-heart simulations of human electromechanical activity, and (5) what human data are currently needed and how to obtain them. The recommendations can be found on the NHLBI Web site at http://www.nhlbi.nih.gov/meetings/workshops/electro.htm.

Fundamental and applied biological sciences. Psychology

Cardiology. Vascular system

General aspects

Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous

Biological and medical sciences

Medical sciences

Vertebrates: cardiovascular system

Blood and lymphatic vessels

Details

Title: Subtitle: Systems Approach to Understanding Electromechanical Activity in the Human Heart : A National Heart, Lung, and Blood Institute Workshop Summary
Creators: Yoram RUDY - Departments of Biomedical Engineering, Cell Biology and Physiology, Medicine, Radiology, and Pediatrics and the Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, Mo, United States
Michael J ACKERMAN - Departments of Medicine, Pediatrics, Molecular Pharmacology, and Experimental Therapeutics, Mayo Clinic, Rochester, Minn, United States
Natalia A TRAYANOVA - Biomedical Engineering, Johns Hopkins University, Baltimore, Md, United States
David R VAN WAGONER - Departments of Molecular Cardiology and Molecular Medicine, Cleveland Clinic Lerner College of Medicine-CWRU, Cleveland, Ohio, United States
Andras VARRO - Department of Pharmacology and Pharmacotherapy, University of Szeged, and Division for Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary
James N WEISS - Division of Cardiology, University of California, Los Angeles, United States
David A LATHROP - Division of Cardiovascular Diseases, National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md, United States
Donald M BERS - Department of Pharmacology, University of California, Davis, United States
Colleen E CLANCY - Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY, United States
Steven R HOUSER - Department of Physiology, Temple University School of Medicine, Philadelphia, Pa, United States
Barry LONDON - Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pa, United States
Andrew D MCCULLOCH - Bioengineering Department, University of California, San Diego, La Jolla, United States
Dennis A PRZYWARA - Division of Cardiovascular Diseases, National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md, United States
Randall L RASMUSSON - Department of Physiology and Biophysics, State Universities of New York, Buffalo, United States
R. John SOLARO - Department of Physiology and Biophysics, and Center for Cardiovascular Research, University of Illinois, Chicago, United States
Resource Type: Journal article
Publication Details: Circulation (New York, N.Y.), Vol.118(11), pp.1202-1211
DOI: 10.1161/CIRCULATIONAHA.108.772715
PMID: 18779456
PMCID: PMC2908516
NLM abbreviation: Circulation
ISSN: 0009-7322
eISSN: 1524-4539
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
Language: English
Date published: 2008
Academic Unit: Molecular Physiology and Biophysics; Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984025328902771

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