Journal article
T Cell Co-Stimulatory Molecules: A Co-conspirator in the Pathogenesis of Eosinophilic Esophagitis?
Digestive diseases and sciences, Vol.58(6), pp.1497-1506
06/01/2013
DOI: 10.1007/s10620-013-2599-8
PMID: 23456499
Abstract
Eosinophilic esophagitis (EoE) has become a common gastrointestinal disease. It is characterized by severe eosinophil infiltration in the esophagus. EoE is strongly associated with food allergy, asthma, atopic dermatitis, and other allergic diseases. T lymphocytes, especially Th2 cells, play an instrumental role in the development of allergic inflammation. Recent studies have shown that the ligation of co-stimulatory molecules contributes to the activation, differentiation, and proliferation of T cells. In this review, we will discuss the growing evidence of co-stimulatory molecules including OX40, Light, and HVEM in the pathogenesis of Th2-driven EoE. Our goal is to provide the rationale for the development of novel therapy therapies that target co-stimulatory molecules.
Details
- Title: Subtitle
- T Cell Co-Stimulatory Molecules: A Co-conspirator in the Pathogenesis of Eosinophilic Esophagitis?
- Creators
- Zili Zhang - Case Western Reserve UniversityThomas J. Sferra - Case Western Reserve UniversityYasemen Eroglu - Oregon Health & Science University
- Resource Type
- Journal article
- Publication Details
- Digestive diseases and sciences, Vol.58(6), pp.1497-1506
- Publisher
- Springer Nature
- DOI
- 10.1007/s10620-013-2599-8
- PMID
- 23456499
- ISSN
- 0163-2116
- eISSN
- 1573-2568
- Number of pages
- 10
- Grant note
- Takeda Pharmaceuticals USA, Inc.
- Language
- English
- Date published
- 06/01/2013
- Academic Unit
- Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9984694751002771
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