Journal article
T Cell Fates Zipped Up: How the Bach2 Basic Leucine Zipper Transcriptional Repressor Directs T Cell Differentiation and Function
The Journal of immunology (1950), Vol.197(4), pp.1009-1015
08/15/2016
DOI: 10.4049/jimmunol.1600847
PMCID: PMC4978142
PMID: 27496973
Abstract
Recent data illustrate a key role for the transcriptional regulator bric-a-brac, tramtrack, and broad complex and cap'n'collar homology (Bach)2 in orchestrating T cell differentiation and function. Although Bach2 has a well-described role in B cell differentiation, emerging data show that Bach2 is a prototypical member of a novel class of transcription factors that regulates transcriptional activity in T cells at super-enhancers, or regions of high transcriptional activity. Accumulating data demonstrate specific roles for Bach2 in favoring regulatory T cell generation, restraining effector T cell differentiation, and potentiating memory T cell development. Evidence suggests that Bach2 regulates various facets of T cell function by repressing other key transcriptional regulators such as B lymphocyte-induced maturation protein 1. In this review, we examine our present understanding of the role of Bach2 in T cell function and highlight the growing evidence that this transcriptional repressor functions as a key regulator involved in maintenance of T cell quiescence, T cell subset differentiation, and memory T cell generation.
Details
- Title: Subtitle
- T Cell Fates Zipped Up: How the Bach2 Basic Leucine Zipper Transcriptional Repressor Directs T Cell Differentiation and Function
- Creators
- Martin J Richer - Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada; Microbiome and Disease Tolerance Centre, McGill University, Montreal, Quebec H3A 2B4, Canada; martin.j.richer@mcgill.ca noah-butler@ouhsc.eduMark L Lang - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Graduate Program in Biosciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104Noah S Butler - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Graduate Program in Biosciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104 martin.j.richer@mcgill.ca noah-butler@ouhsc.edu
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.197(4), pp.1009-1015
- DOI
- 10.4049/jimmunol.1600847
- PMID
- 27496973
- PMCID
- PMC4978142
- NLM abbreviation
- J Immunol
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Publisher
- United States
- Grant note
- R01 AI078993 / NIAID NIH HHS R01 AI125446 / NIAID NIH HHS R56 AI078993 / NIAID NIH HHS P20 GM103447 / NIGMS NIH HHS
- Language
- English
- Date published
- 08/15/2016
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984001150502771
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