Journal article
T-Lymphocyte Dysregulation in Asthma
Proceedings of the Society for Experimental Biology and Medicine, Vol.207(3), pp.243-253
12/1994
DOI: 10.3181/00379727-207-43813A
PMID: 7800679
Abstract
Summary
In this paper, we have reviewed the evidence suggesting that T-cell dysregulation is important in the pathogenesis of asthma. The history, clinical presentation, and an overview of the appropriate management of asthma have been briefly reviewed. T cells obtained from the airways of asthmatics display signs of activation; these changes mirror the intramural inflammation found at biopsy. There is debate about the importance of T helper/suppressor ratios in this population of cells, but alterations in these ratios have been noted with experimental allergen exposure, as well as during acute asthma attacks; some of these changes revert toward normal with steroid therapy. The division of T helper lymphocytes into Th1 and Th2 cells, first described in studies of murine immunology, appear to be relevant in humans, particularly in allergic disease. Although IL-4 and IL-5, prototypical Th2 cytokines, have been most clearly implicated in asthma, there is some evidence supporting a role for Th1 cells/cytokines as well.
Details
- Title: Subtitle
- T-Lymphocyte Dysregulation in Asthma
- Creators
- Joel N KlineGary W Hunninghake
- Resource Type
- Journal article
- Publication Details
- Proceedings of the Society for Experimental Biology and Medicine, Vol.207(3), pp.243-253
- Publisher
- SAGE Publications
- DOI
- 10.3181/00379727-207-43813A
- PMID
- 7800679
- ISSN
- 0037-9727
- eISSN
- 1535-3699
- Language
- English
- Date published
- 12/1994
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Occupational and Environmental Health; Internal Medicine
- Record Identifier
- 9984094608102771
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