Journal article
T and B cell subsets differentially correlate with amyloid deposition and neurocognitive function in patients with amnestic mild cognitive impairment after one year of physical activity
Exercise immunology review, Vol.25, pp.34-49
2019
PMCID: PMC6756851
PMID: 30785868
Abstract
Individuals with amnestic mild cognitive impairment (aMCI) experience cognitive declines in learning and memory greater than expected for normal aging, and are at a high risk of dementia. We previously reported that sedentary aMCI patients exhibited neuroinflammation that correlated with brain amyloid beta (Aβ) burden, as determined by 18F-florbetapir positron emission tomography (PET). These aMCI patients enrolled in a one-year randomized control trial (AETMCI, NCT01146717) to test the beneficial effects of 12 months of moderate-to-high intensity aerobic exercise training (AET) or stretching/toning (ST) control intervention on neurocognitive function. A subset of aMCI participants had PET imaging, cognitive testing, and immunophenotyping of cerebrospinal fluid (CSF) and peripheral blood after AET or ST interventions. As adaptive immune responses were similar between AET and ST groups, we combined AET/ST into a general 'physical activity' (PA) group and compared Aβ burden, cognitive function, and adaptive immune cell subsets to sedentary lifestyle before intervention. We found that PAinduced immunomodulation of CD4+ and CD8+ T cells in CSF correlated with changes in Aβ burden in brain regions associated with executive function. Furthermore, after PA, cognitive scores on tests of memory, processing speed, attention, verbal fluency, and executive function were associated with increased percent representation of circulating naïve B + T cells. We review the literature on aMCI-related cognition and immune changes as they relate to exercise, and highlight how our preliminary data suggest a complex interplay between the adaptive immune system, physical activity, cognition, and Aβ burden in aMCI.
Details
- Title: Subtitle
- T and B cell subsets differentially correlate with amyloid deposition and neurocognitive function in patients with amnestic mild cognitive impairment after one year of physical activity
- Creators
- Katherine Poinsatte - Dept. of Neurology & Neurotherapeutics, UT Southwestern Medical Center, 6000 Harry Hines, Dallas, TX, 75390, USAEmily E Smith - The University of Texas Southwestern Medical CenterVanessa O Torres - Dept. of Neurology & Neurotherapeutics, UT Southwestern Medical Center, 6000 Harry Hines, Dallas, TX, 75390, USASterling B Ortega - Dept. of Neurology & Neurotherapeutics, UT Southwestern Medical Center, 6000 Harry Hines, Dallas, TX, 75390, USARyan M Huebinger - Dept. of Surgery, UT Southwestern Medical Center, 6000 Harry Hines, Dallas, TX, 75390, USAC Munro Cullum - Dept. of Neurology & Neurotherapeutics, UT Southwestern Medical Center, 6000 Harry Hines, Dallas, TX, 75390, USA. Dept. of Psychiatry, UT Southwestern Medical Center, 5323 Harry Hines, Dallas, TX, 75390, USANancy L Monson - Dept. of Neurology & Neurotherapeutics, UT Southwestern Medical Center, 6000 Harry Hines, Dallas, TX, 75390, USA. Dept. of Immunology, UT Southwestern Medical Center, 6000 Harry Hines, Dallas, TX, 75390, USARhong Zhang - Dept. of Neurology & Neurotherapeutics, UT Southwestern Medical Center, 6000 Harry Hines, Dallas, TX, 75390, USA. Insitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, 7232 Greenville Ave., Dallas, TX, 75231, USA 6 Dept. of NeurologyAnn M Stowe - Dept. of Neurology & Neurotherapeutics, UT Southwestern Medical Center, 6000 Harry Hines, Dallas, TX, 75390, USA. Dept. of Neurology, University of Kentucky, 741 S. Limestone St, Lexington, KY, 40506, USA
- Resource Type
- Journal article
- Publication Details
- Exercise immunology review, Vol.25, pp.34-49
- Publisher
- Germany
- PMID
- 30785868
- PMCID
- PMC6756851
- ISSN
- 1077-5552
- Language
- English
- Date published
- 2019
- Academic Unit
- Pathology
- Record Identifier
- 9984065377402771
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