T-cell activation after chronic ethanol ingestion in mice

Robert T Cook; Xiaoyan Zhu; Ruth A Coleman; Zuhair K Ballas; Thomas J Waldschmidt; Nancy B Ray; Douglas R LaBrecque; Brian L Cook

doi:10.1016/j.alcohol.2004.06.007

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T-cell activation after chronic ethanol ingestion in mice

Journal article

Peer reviewed

T-cell activation after chronic ethanol ingestion in mice

Robert T Cook, Xiaoyan Zhu, Ruth A Coleman, Zuhair K Ballas, Thomas J Waldschmidt, Nancy B Ray, Douglas R LaBrecque and Brian L Cook

Alcohol (Fayetteville, N.Y.), Vol.33(3), pp.175-181

2004

DOI: 10.1016/j.alcohol.2004.06.007

PMID: 15596085

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Abstract

Chronic excessive consumption of ethanol causes immunodeficiency in human beings and in mice. Immunologic changes have been described in both species, including T-cell and innate immune system cell activation, among others. The features of chronic ethanol-induced activation have similarities in the two species, including an increased effector subset in both CD4 + and CD8 + T cells. There are also features of activation observed in the splenic macrophages of mice consuming ethanol chronically, including increased up-regulation of CD80 and CD86. Because these molecules are involved in T-cell–antigen-presenting cell interactions in vivo, it is of interest to ask whether these and other pathways of interaction are important in the T-cell activation and cytokine skewing described in chronic ethanol abuse. Preliminary findings from comparisons of wild-type, CD40 ligand knock-out, and CD28 knock-out C57BL/6 mice strongly support the suggestion of a critical role for T-cell–antigen-presenting cell interactions in the immune alterations observed in chronic ethanol abuse.

T cells

Alcohol

T-cell–APC interactions

Details

Title: Subtitle: T-cell activation after chronic ethanol ingestion in mice
Creators: Robert T Cook - Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Xiaoyan Zhu - Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Ruth A Coleman - Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Zuhair K Ballas - Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Thomas J Waldschmidt - Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Nancy B Ray - Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Douglas R LaBrecque - Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Brian L Cook - Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Alcohol (Fayetteville, N.Y.), Vol.33(3), pp.175-181
DOI: 10.1016/j.alcohol.2004.06.007
PMID: 15596085
NLM abbreviation: Alcohol
ISSN: 0741-8329
eISSN: 1873-6823
Publisher: Elsevier
Language: English
Date published: 2004
Academic Unit: Psychiatry; Microbiology and Immunology; Stead Family Department of Pediatrics; Gastroenterology and Hepatology; Pathology; Immunology; Internal Medicine
Record Identifier: 9984046922902771

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