T-cell activation and memory phenotypes in cerebrospinal fluid during HIV infection

Jutta K NEUENBURG; Tracey A CHO; Annelie NILSSON; Barry M BREDT; Samuel J HEBERT; Robert M GRANT; Richard W PRICE

doi:10.1097/01.qai.0000155036.03004.a0

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T-cell activation and memory phenotypes in cerebrospinal fluid during HIV infection

Journal article

Open access

Peer reviewed

T-cell activation and memory phenotypes in cerebrospinal fluid during HIV infection

Jutta K NEUENBURG, Tracey A CHO, Annelie NILSSON, Barry M BREDT, Samuel J HEBERT, Robert M GRANT and Richard W PRICE

Journal of acquired immune deficiency syndromes (1999), Vol.39(1), pp.16-22

2005

DOI: 10.1097/01.qai.0000155036.03004.a0

PMID: 15851909

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Abstract

We characterized T cell phenotypes in 74 paired blood and cerebrospinal fluid (CSF) samples of HIV-infected and uninfected persons using four-color flow cytometry. CD4+ and CD8+ T cells subsets were further characterized by identifying activated/resting and memory/naive subsets in CSF and blood using the markers CD38/HLA-DR and CD45RA/CD62L, respectively. With and without HIV-infection, the proportion of CD4+ T cells and memory T cells among T cells in CSF was higher compared to blood. In HIV-infection, activated CD4+ and CD8+ T cells in CSF were more abundant than in uninfected controls. As expected, combination antiretroviral therapy (ART) reduced T cell activation in CSF and blood.

Infectious Diseases

Microbiology

Virology

Fundamental and applied biological sciences. Psychology

Miscellaneous

Viral diseases

Viral diseases of the lymphoid tissue and the blood. Aids

Biological and medical sciences

Medical sciences

Human viral diseases

Details

Title: Subtitle: T-cell activation and memory phenotypes in cerebrospinal fluid during HIV infection
Creators: Jutta K NEUENBURG - Department of Neurology, tGladstone Institute of Virology and Immunology, General Clinical Research Center at the University of California, San Francisco, United States
Tracey A CHO - Department of Neurology, tGladstone Institute of Virology and Immunology, General Clinical Research Center at the University of California, San Francisco, United States
Annelie NILSSON - Department of Neurology, tGladstone Institute of Virology and Immunology, General Clinical Research Center at the University of California, San Francisco, United States
Barry M BREDT - Department of Medicine and the San Francisco General Hospital, General Clinical Research Center at the University of California, San Francisco, United States
Samuel J HEBERT - Department of Neurology, tGladstone Institute of Virology and Immunology, General Clinical Research Center at the University of California, San Francisco, United States
Robert M GRANT - Department of Neurology, tGladstone Institute of Virology and Immunology, General Clinical Research Center at the University of California, San Francisco, United States
Richard W PRICE - Department of Neurology, tGladstone Institute of Virology and Immunology, General Clinical Research Center at the University of California, San Francisco, United States
Resource Type: Journal article
Publication Details: Journal of acquired immune deficiency syndromes (1999), Vol.39(1), pp.16-22
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
DOI: 10.1097/01.qai.0000155036.03004.a0
PMID: 15851909
ISSN: 1525-4135
eISSN: 1944-7884
Language: English
Date published: 2005
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984020859202771

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