T-cell anergy and altered T-cell receptor signaling: effects on autoimmune disease

Konstantin V Salojin; Jian Zhang; Joaquin Madrenas; Terry L Delovitch

doi:10.1016/S0167-5699(98)01326-7

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Journal article

T-cell anergy and altered T-cell receptor signaling: effects on autoimmune disease

Konstantin V Salojin, Jian Zhang, Joaquin Madrenas and Terry L Delovitch

Immunology today (Amsterdam. Regular ed.), Vol.19(10), pp.468-473

1998

DOI: 10.1016/S0167-5699(98)01326-7

PMID: 9785671

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Abstract

Immunological self-tolerance can be acquired by several mechanisms, including the induction of anergy in autoreactive T cells. In this sense, anergy is predictably advantageous for the immune system. Here, Konstantin Salojin and colleagues present an alternative view that the induction of anergy in regulatory T cells may be harmful to the host and elicit autoimmune disease.

Details

Title: Subtitle: T-cell anergy and altered T-cell receptor signaling: effects on autoimmune disease
Creators: Konstantin V Salojin - Autoimmunity/Diabetes Group, The John P. Robarts Research Institute, and the Depts of Microbiology and Immunology, and Medicine, University of Western Ontario, London, Ontario, Canada N6A 5K8
Jian Zhang - University of Iowa, Pathology
Joaquin Madrenas - Transplantation and Immunobiology Group, The John P. Robarts Research Institute, and the Depts of Microbiology and Immunology, and Medicine, University of Western Ontario, London, Ontario, Canada N6A 5K8
Terry L Delovitch
Resource Type: Journal article
Publication Details: Immunology today (Amsterdam. Regular ed.), Vol.19(10), pp.468-473
Publisher: Elsevier B.V
DOI: 10.1016/S0167-5699(98)01326-7
PMID: 9785671
ISSN: 0167-5699
Language: English
Date published: 1998
Academic Unit: Pathology
Record Identifier: 9984195953302771

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