Journal article
T cell conditioning explains early disappearance of the memory CD8 T cell response to infection
The Journal of immunology (1950), Vol.177(5), pp.3012-3018
09/01/2006
DOI: 10.4049/jimmunol.177.5.3012
PMID: 16920937
Abstract
Memory CD8 T cells respond more rapidly to acute intracellular infections than naive CD8 T cells. An understanding of the biological processes involved in memory CD8 T cell recognition of Ag and up-regulation of effector mechanism necessitates analyzing memory CD8 T cells at early time points after infection. In the current study, we show that memory CD8 T cells ostensibly disappear from the spleens, blood, and peripheral organs of mice early after infection with Listeria monocytogenes. This disappearance is critically dependent on Ag, and cell-associated Ag alone can mediate this phenomenon. Further investigations, however, suggest that this disappearance is secondary to T cell-APC interactions, also known as T cell conditioning, and disruption of these putative interactions during splenic processing improves recovery of Ag-specific memory CD8 T cell populations after immunization. Conventional analyses of memory CD8 T cell populations early after infection and possibly in the presence of low levels of Ag (as during chronic infections) may exclude significant numbers of the responding CD8 T cell population.
Details
- Title: Subtitle
- T cell conditioning explains early disappearance of the memory CD8 T cell response to infection
- Creators
- Ali Jabbari - Interdisciplinary Graduate Program in Immunology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USAKevin L LeggeJohn T Harty
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.177(5), pp.3012-3018
- DOI
- 10.4049/jimmunol.177.5.3012
- PMID
- 16920937
- NLM abbreviation
- J Immunol
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Publisher
- United States
- Grant note
- AI42767 / NIAID NIH HHS AI50073 / NIAID NIH HHS AI059752 / NIAID NIH HHS AI46653 / NIAID NIH HHS
- Language
- English
- Date published
- 09/01/2006
- Academic Unit
- Dermatology; Microbiology and Immunology; Pathology
- Record Identifier
- 9984025678902771
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