T-cell infiltration in autosomal dominant neovascular inflammatory vitreoretinopathy

Vinit B Mahajan; John G Vallone; Jonathan H Lin; Robert F Mullins; Audrey C Ko; James C Folk; Edwin M Stone

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T-cell infiltration in autosomal dominant neovascular inflammatory vitreoretinopathy

Journal article

Peer reviewed

T-cell infiltration in autosomal dominant neovascular inflammatory vitreoretinopathy

Vinit B Mahajan, John G Vallone, Jonathan H Lin, Robert F Mullins, Audrey C Ko, James C Folk and Edwin M Stone

Molecular vision, Vol.16(114-15), pp.1034-1040

06/08/2010

PMCID: PMC2893052

PMID: 20596252

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Abstract

Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is a familial blinding disease of unknown pathophysiology. The eyes and sera from patients with ADNIV were studied to understand the immune response in this condition. The clinical case of an ADNIV patient was reviewed. Eye specimens from two donors with ADNIV were examined with a panel of standard histopathological stains and immunohistochemical markers. These findings were compared to specimens of noninflammatory eye disease. Sera from twelve patients were also tested against retinal protein western blots for the presence of autoretinal antibodies. Each of the ADNIV and control eyes showed degenerative features of phthisis bulbi. Immunohistological stains revealed a supraciliary T-cell infiltrate in ADNIV eyes composed of cluster of differentiation-4 (CD4) positive and cluster of differentiation-8 (CD8)-positive cells. No immunoglobulin or B cells were detected in these eyes. Inflammatory cells were absent from the control eyes. No specific autoretinal antibodies were detected in ADNIV sera. Aberrant T-cell-mediated processes may underlie ADNIV, and therapeutics directed at T cells may better manage inflammation in these patients. Genes related to T-cell function are high priority screening candidates.

Retinal Diseases - genetics

Eye Diseases - immunology

Retinal Diseases - immunology

Immunologic Techniques

Autoantibodies - blood

Humans

Retina - immunology

CD8 Antigens - analysis

Neovascularization, Pathologic - pathology

Eye Diseases - genetics

Genes, Dominant

CD4 Antigens - analysis

Staining and Labeling

Aged, 80 and over

Retinal Diseases - pathology

Vitreous Body

Female

Neovascularization, Pathologic - genetics

Immunoglobulin G - analysis

Neovascularization, Pathologic - immunology

B-Lymphocytes - pathology

T-Lymphocytes - pathology

Eye Diseases - pathology

Details

Title: Subtitle: T-cell infiltration in autosomal dominant neovascular inflammatory vitreoretinopathy
Creators: Vinit B Mahajan - Vitreoretinal Service, Department of Ophthalmology and Visual Sciences, The University of Iowa Hospitals & Clinics, Iowa City, IA, USA
John G Vallone
Jonathan H Lin
Robert F Mullins
Audrey C Ko
James C Folk
Edwin M Stone
Resource Type: Journal article
Publication Details: Molecular vision, Vol.16(114-15), pp.1034-1040
PMID: 20596252
PMCID: PMC2893052
NLM abbreviation: Mol Vis
ISSN: 1090-0535
eISSN: 1090-0535
Publisher: United States
Grant note: K08 EY018313-03S1 / NEI NIH HHS K08 EY018313 / NEI NIH HHS Howard Hughes Medical Institute R01 EY020846 / NEI NIH HHS K08 EY018313-03 / NEI NIH HHS
Language: English
Date published: 06/08/2010
Academic Unit: Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983980088302771

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