T-cell mediated immunity and the role of TRAIL in sepsis-induced immunosuppression

Stephanie A Condotta; Javier Cabrera-Perez; Vladimir P Badovinac; Thomas S Griffith

doi:10.1615/CritRevImmunol.2013006721

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T-cell mediated immunity and the role of TRAIL in sepsis-induced immunosuppression

Journal article

Open access

Peer reviewed

T-cell mediated immunity and the role of TRAIL in sepsis-induced immunosuppression

Stephanie A Condotta, Javier Cabrera-Perez, Vladimir P Badovinac and Thomas S Griffith

Critical reviews in immunology, Vol.33(1), pp.23-40

2013

DOI: 10.1615/CritRevImmunol.2013006721

PMCID: PMC3625932

PMID: 23510024

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https://www.ncbi.nlm.nih.gov/pmc/articles/3625932View

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Abstract

Sepsis is the leading cause of death in most intensive care units, and the death of septic patients usually does not result from the initial septic event but rather from subsequent nosocomial infections. Patients who survive severe sepsis often display severely compromised immune function. Not only is there significant apoptosis of lymphoid and myeloid cells that depletes critical components of the immune system during sepsis, there is also decreased function of the remaining immune cells. Studies in animals and humans suggest the immune defects that occur during sepsis may be critical to the pathogenesis and subsequent mortality. This review is focused on sepsis-induced alterations with the CD8 T-cell compartment that can affect the control of secondary heterologous infections. Understanding how a septic event directly influences CD8 T-cell populations through apoptotic death and homeostatic proliferation and indirectly by immune-mediated suppression will provide valuable starting points for developing new treatment options.

Sepsis

apoptosis

TRAIL

CD8 T-cells

tolerance

homeostatic proliferation

Details

Title: Subtitle: T-cell mediated immunity and the role of TRAIL in sepsis-induced immunosuppression
Creators: Stephanie A Condotta - Department of Pathology, University of Iowa, Iowa City, IA 52242
Javier Cabrera-Perez - Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, MN 55455
Vladimir P Badovinac - Department of Pathology, University of Iowa, Iowa City, IA 52242
Thomas S Griffith - Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, MN 55455
Resource Type: Journal article
Publication Details: Critical reviews in immunology, Vol.33(1), pp.23-40
DOI: 10.1615/CritRevImmunol.2013006721
PMID: 23510024
PMCID: PMC3625932
NLM abbreviation: Crit Rev Immunol
ISSN: 1040-8401
eISSN: 2162-6472
Grant note: R01 AI083286 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID
Language: English
Date published: 2013
Academic Unit: Microbiology and Immunology; Pathology
Record Identifier: 9984047698002771

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