Journal article
T cell-mediated immunity to malaria
Nature reviews. Immunology, Vol.19(7), pp.457-471
07/2019
DOI: 10.1038/s41577-019-0158-z
PMCID: PMC6599480
PMID: 30940932
Abstract
Immunity to malaria has been linked to the availability and function of helper CD4
T cells, cytotoxic CD8
T cells and γδ T cells that can respond to both the asymptomatic liver stage and the symptomatic blood stage of Plasmodium sp. infection. These T cell responses are also thought to be modulated by regulatory T cells. However, the precise mechanisms governing the development and function of Plasmodium-specific T cells and their capacity to form tissue-resident and long-lived memory populations are less well understood. The field has arrived at a point where the push for vaccines that exploit T cell-mediated immunity to malaria has made it imperative to define and reconcile the mechanisms that regulate the development and functions of Plasmodium-specific T cells. Here, we review our current understanding of the mechanisms by which T cell subsets orchestrate host resistance to Plasmodium infection on the basis of observational and mechanistic studies in humans, non-human primates and rodent models. We also examine the potential of new experimental strategies and human infection systems to inform a new generation of approaches to harness T cell responses against malaria.
Details
- Title: Subtitle
- T cell-mediated immunity to malaria
- Creators
- Samarchith P Kurup - University of IowaNoah S Butler - University of IowaJohn T Harty - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Nature reviews. Immunology, Vol.19(7), pp.457-471
- DOI
- 10.1038/s41577-019-0158-z
- PMID
- 30940932
- PMCID
- PMC6599480
- NLM abbreviation
- Nat Rev Immunol
- ISSN
- 1474-1733
- eISSN
- 1474-1741
- Grant note
- R37 AI042767 / NIAID NIH HHS R01 AI095178 / NIAID NIH HHS R01 AI100527 / NIAID NIH HHS R01 AI127481 / NIAID NIH HHS R01 AI042767 / NIAID NIH HHS R01 AI085515 / NIAID NIH HHS R21 AI042767 / NIAID NIH HHS R01 AI125446 / NIAID NIH HHS
- Language
- English
- Date published
- 07/2019
- Academic Unit
- Molecular Physiology and Biophysics; Microbiology and Immunology; Pathology
- Record Identifier
- 9984186551902771
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