Journal article
T-cell properties determine disease site, clinical presentation, and cellular pathology of experimental autoimmune encephalomyelitis
The American journal of pathology, Vol.165(5), pp.1519-1533
2004
DOI: 10.1016/S0002-9440(10)63410-4
PMCID: PMC1618652
PMID: 15509523
Abstract
Two distinct clinical phenotypes of experimental autoimmune encephalomyelitis are observed in BALB interferon-γ knockout mice immunized with encephalitogenic peptides of myelin basic protein. Conventional disease, characterized by ascending weakness and paralysis, occurs with greater frequency after immunizing with a peptide comprising residues 59 to 76. Axial-rotatory disease, characterized by uncontrolled axial rotation, occurs with greater frequency in mice immunized with a peptide corresponding to exon 2 of the full length 21.5-kd protein. The two clinical phenotypes are histologically distinguishable. Conventional disease is characterized by inflammation and demyelination primarily in spinal cord, whereas axial-rotatory disease involves inflammation and demyelination of lateral medullary areas of brain. Both types have infiltrates in which neutrophils are a predominating component. By isolating T cells and transferring disease to naïve recipients, we show here that the type of disease is determined entirely by the inducing T cell. Furthermore, studies using CXCR2 knockout recipients, unable to recruit neutrophils to inflammatory sites, show that although neutrophils are critical for some of these T cells to effect disease, there are also interferon-γ-deficient T cells that induce disease in the absence of both interferon-γ and neutrophils. These results highlight the multiplicity of T-cell-initiated effector pathways available for inflammation and demyelination.
Details
- Title: Subtitle
- T-cell properties determine disease site, clinical presentation, and cellular pathology of experimental autoimmune encephalomyelitis
- Creators
- Sara ABROMSON-LEEMAN - Harvard UniversityRod Bronson - Harvard UniversityY I Luo - Harvard UniversityMichael Berman - Harvard UniversityRebecca Leeman - Harvard UniversityJoshua Leeman - Harvard UniversityMartin Dorf - Harvard University
- Resource Type
- Journal article
- Publication Details
- The American journal of pathology, Vol.165(5), pp.1519-1533
- Publisher
- American Society for Investigative Pathology
- DOI
- 10.1016/S0002-9440(10)63410-4
- PMID
- 15509523
- PMCID
- PMC1618652
- ISSN
- 0002-9440
- eISSN
- 1525-2191
- Language
- English
- Date published
- 2004
- Academic Unit
- Urology
- Record Identifier
- 9984319968302771
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