Journal article
T-cell recognition of non-peptide antigens
Current opinion in immunology, Vol.8(4), pp.510-516
1996
DOI: 10.1016/S0952-7915(96)80039-2
PMID: 8794014
Abstract
Studies of two distinct human T-cell systems have provided the exciting finding that T cells are able to recognize non-peptide antigens: γδ T cells have been shown to recognize isopentenyl pyrophosphate and related structures and human CD1 has been shown to present microbial lipids and lipoglycans such as mycolic acids and lipoarabinomannan to T cells. T-cell responses to these non-peptide antigens should provide a strategic target for immunologic intervention in infectious disease.
Details
- Title: Subtitle
- T-cell recognition of non-peptide antigens
- Creators
- Steven A Porcelli - Division of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA 02115, USACraig T Morita - Division of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA 02115, USARobert L Modlin - Division of Dermatology and Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, CA 90095, USA
- Resource Type
- Journal article
- Publication Details
- Current opinion in immunology, Vol.8(4), pp.510-516
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0952-7915(96)80039-2
- PMID
- 8794014
- ISSN
- 0952-7915
- eISSN
- 1879-0372
- Language
- English
- Date published
- 1996
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094509602771
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