Journal article
T follicular helper cell development during malaria
Current opinion in immunology, Vol.97, 102682
12/2025
DOI: 10.1016/j.coi.2025.102682
PMCID: PMC12616646
PMID: 41135202
Abstract
Malaria is a life-threatening disease affecting more than 200 million people worldwide. CD4 T helper 1 (Th1) and T follicular helper (Tfh) cells are critical for stimulating phagocyte activation and humoral immunity, yet sterilizing, protective immune memory responses rarely develop. Malaria induces unique physiologic changes in the infected host that may give rise to nonconventional Tfh subsets and inefficient memory responses. While our understanding of the differentiation of conventional Tfh cells induced by Plasmodium infection is growing, how and whether malaria-associated environmental cues induce Tfh populations exhibiting mixed phenotype and function are not well defined. Moreover, little is known about the development and function of Tfh memory cells during malaria. In this review, we discuss the phenotype and known functions of Tfh subsets and memory development induced during malaria and highlight key priority knowledge gaps that remain to be addressed.
Details
- Title: Subtitle
- T follicular helper cell development during malaria
- Creators
- Regina M Antonetti - University of IowaManan Shah - University of IowaNoah S Butler - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Current opinion in immunology, Vol.97, 102682
- DOI
- 10.1016/j.coi.2025.102682
- PMID
- 41135202
- PMCID
- PMC12616646
- NLM abbreviation
- Curr Opin Immunol
- ISSN
- 0952-7915
- eISSN
- 1879-0372
- Publisher
- Elsevier
- Grant note
- Institutes of Health (NIH, USA): AI125446, AI127481, AI167058 NIH, USA: AI007485
Institutes of Health (NIH, USA) grants AI125446, AI127481, and AI167058 to N.S.B. R.M.A. is supported by (NIH, USA) grant AI007485.
- Language
- English
- Electronic publication date
- 10/23/2025
- Date published
- 12/2025
- Academic Unit
- Molecular Physiology and Biophysics; Microbiology and Immunology
- Record Identifier
- 9985019036602771
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