Journal article
T1ρ imaging in premanifest Huntington disease reveals changes associated with disease progression
Movement disorders, Vol.30(8), pp.1107-1114
07/2015
DOI: 10.1002/mds.26203
PMCID: PMC4751081
PMID: 25820773
Abstract
Imaging biomarkers sensitive to Huntington's disease (HD) during the premanifest phase preceding motor diagnosis may accelerate identification and evaluation of potential therapies. For this purpose, quantitative MRI sensitive to tissue microstructure and metabolism may hold great potential. We investigated the potential value of T1ρ relaxation to detect pathological changes in premanifest HD (preHD) relative to other quantitative relaxation parameters.\nQuantitative MR parametric mapping was used to assess differences between 50 preHD subjects and 26 age- and sex-matched controls. Subjects with preHD were classified into two progression groups based on their CAG-age product (CAP) score; a high and a low/moderate CAP group. Voxel-wise and region-of-interest analyses were used to assess changes in the quantitative relaxation times.\nT1ρ showed a significant increase in the relaxation times in the high-CAP group, as compared to controls, largely in the striatum. The T1ρ changes in the preHD subjects showed a significant relationship with CAP score. No significant changes in T2 or T2* relaxation times were found in the striatum. T2* relaxation changes were found in the globus pallidus, but no significant changes with disease progression were found.\nThese data suggest that quantitative T1ρ mapping may provide a useful marker for assessing disease progression in HD. The absence of T2 changes suggests that the T1ρ abnormalities are unlikely owing to altered water content or tissue structure. The established sensitivity of T1ρ to pH and glucose suggests that these factors are altered in HD perhaps owing to abnormal mitochondrial function.
Details
- Title: Subtitle
- T1ρ imaging in premanifest Huntington disease reveals changes associated with disease progression
- Creators
- Shafik N Wassef - SINAPSE, Iowa Neuroimaging Consortium, Department of Psychiatry, University of Iowa, Iowa City, Iowa, USAJohn Wemmie - Veterans Affairs Hospital Center, Iowa City, IA, USACasey P Johnson - Department of Radiology, University of Iowa, Iowa City, Iowa, USAHans Johnson - SINAPSE, Iowa Neuroimaging Consortium, Department of Psychiatry, University of Iowa, Iowa City, Iowa, USAJane S Paulsen - Department of Psychology, University of Iowa, Iowa City, Iowa, USAJeffrey D Long - Department of Biostatistics, University of Iowa, Iowa City, Iowa, USAVincent A Magnotta - Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Movement disorders, Vol.30(8), pp.1107-1114
- DOI
- 10.1002/mds.26203
- PMID
- 25820773
- PMCID
- PMC4751081
- NLM abbreviation
- Mov Disord
- ISSN
- 0885-3185
- eISSN
- 1531-8257
- Publisher
- United States
- Grant note
- U54 EB005149 / NIBIB NIH HHS\nR01 NS040068 / NINDS NIH HHS\nR01 NS054893 / NINDS NIH HHS\nS10 RR023392 / NCRR NIH HHS\nR01 NS050568 / NINDS NIH HHS\nI01 BX000741 / BLRD VA\nP41 RR015241 / NCRR NIH HHS
- Language
- English
- Date published
- 07/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Biostatistics; Neurosurgery
- Record Identifier
- 9984066392002771
Metrics
15 Record Views