T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility

Michella Ghassibe-Sabbagh; Marc Haber; Angelique K. Salloum; Yasser Al-Sarraj; Yasmine Akle; Kamal Hirbli; Jihane Romanos; Francis Mouzaya; Dominique Gauguier; Daniel E. Platt; Hatem El-Shanti; Pierre A. Zalloua

doi:10.1038/srep07351

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T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility

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T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility

Michella Ghassibe-Sabbagh, Marc Haber, Angelique K. Salloum, Yasser Al-Sarraj, Yasmine Akle, Kamal Hirbli, Jihane Romanos, Francis Mouzaya, Dominique Gauguier, Daniel E. Platt, …

Scientific reports, Vol.4(1), pp.7351-7351

12/08/2014

DOI: 10.1038/srep07351

PMCID: PMC5376673

PMID: 25483131

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Abstract

Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 x 10(-9)) and rs34872471 (OR = 1.35, P = 1.01 x 10(-8)) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.

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Title: Subtitle: T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility
Creators: Michella Ghassibe-Sabbagh - Lebanese American University
Marc Haber - Lebanese American University
Angelique K. Salloum - Lebanese American University
Yasser Al-Sarraj - Shafallah Center
Yasmine Akle - Centre Hospitalier du Nord-CHN, Zgharta, Lebanon.
Kamal Hirbli - University Medical Center Rizk Hospital
Jihane Romanos - Lebanese American University
Francis Mouzaya - Lebanese American University
Dominique Gauguier - Centre de Recherche des Cordeliers
Daniel E. Platt - IBM (United States)
Hatem El-Shanti - University of Iowa
Pierre A. Zalloua - Lebanese American University
Resource Type: Journal article
Publication Details: Scientific reports, Vol.4(1), pp.7351-7351
DOI: 10.1038/srep07351
PMID: 25483131
PMCID: PMC5376673
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Publisher: Springer Nature
Number of pages: 9
Grant note: NPRP 09-215-3-049 / Qatar National Research Fund; Qatar National Research Fund (QNRF)
Language: English
Date published: 12/08/2014
Academic Unit: Stead Family Department of Pediatrics; Medical Genetics and Genomics
Record Identifier: 9984353936502771

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