Journal article
TGF-beta Regulation of Focal Adhesion Proteins and Motility of Premalignant Oral Lesions via Protein Phosphatase 1
Anticancer research, Vol.31(10), pp.3159-3164
10/01/2011
PMCID: PMC3622218
PMID: 21965722
Abstract
Premalignant oral lesions have a high incidence of recurrence and progression to malignant disease and, although studies have shown the contribution of transforming growth factor beta (TGF-beta) to cancer progression, none have been conducted with premalignant oral lesion cells to determine the impact of TGF-beta in stimulating properties that are characteristic of more invasive cells. The present study focused on TGF-beta-modulation of paxillin and the serine/threonine protein phosphatase PP-I, and the impact on cellular motility. These studies show that TGF-beta stimulates premalignant lesion cell motility and up regulates expression of paxillin, as well as its co-localization with PP-I, while concurrently diminishing the level of paxillin serine phosphorylation. The TGF-beta-mediated up regulation of paxillin and co-localization with actin, as well as the TGF-beta-stimulated motility of premalignant lesion cells, were all blocked by inhibiting PP-I, indicating their dependence on PP-1 activity. These studies suggest interplay between TGF-beta and PP-1 in promoting a more malignant phenotype in premalignant oral lesion cells.
Details
- Title: Subtitle
- TGF-beta Regulation of Focal Adhesion Proteins and Motility of Premalignant Oral Lesions via Protein Phosphatase 1
- Creators
- Jarrett E. Walsh - Ralph H Johnson Vet Affairs Med Ctr, Res Serv, Charleston, SC USAM. Rita I. Young - Ralph H Johnson Vet Affairs Med Ctr, Res Serv, Charleston, SC USA
- Resource Type
- Journal article
- Publication Details
- Anticancer research, Vol.31(10), pp.3159-3164
- Publisher
- Int Inst Anticancer Research
- PMID
- 21965722
- PMCID
- PMC3622218
- ISSN
- 0250-7005
- eISSN
- 1791-7530
- Number of pages
- 6
- Grant note
- R01 DE018168; R01CA128837 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Clinical Science and Biomedical Laboratory Research and Development Services of the Department of Veterans Affairs R01CA045080 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01DE018168 / NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR)
- Language
- English
- Date published
- 10/01/2011
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984312248902771
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