Journal article
THE COMBINED-ACTION OF ICI-D1694, 5-FLUORO-2'-DEOXYURIDINE AND 5-FLUOROURACIL IN INHIBITING THE GROWTH OF A HUMAN RENAL-CELL CARCINOMA CELL-LINE (RPMI-SE) IN-VITRO
International journal of oncology, Vol.4(1), pp.137-141
01/01/1994
DOI: 10.3892/ijo.4.1.137
PMID: 21566903
Abstract
In order to investigate possible interactions among ICI-D1694 (a new folate-analog thymidylate synthase inhibitor), 5-fluoro-2'-deoxyuridine (FdUrd) and 5-fluorouracil (FUra), the effect of these agents alone and in 2-drug combinations against a human renal cell carcinoma cell line (RPMI-SE) in vitro was investigated. The median IC50's for cell growth inhibition for ICI-D1694, FdUrd and FUra were 4.00, 7.23 and 1,340 nM, respectively. To quantitatively assess the degree of agent-combined action for 2-agent combinations of the 3 drugs, data from combination experiments were fitted with a response surface mathematical model (Greco et al, Cancer Res 50: 5318-5327, 1990). In 3 experiments for each combination, moderate Loewe synergism was consistently shown for ICI-D1694/FdUrd, less prominent Loewe synergism was indicated for FdUrd/FUra; and Loewe additivity was shown for ICI-D1694/FUra. Studies in vitro to elucidate the mechanism of the interaction of ICI-D1694 + FdURD, and in vivo to establish possible therapeutic advantages are warranted.
Details
- Title: Subtitle
- THE COMBINED-ACTION OF ICI-D1694, 5-FLUORO-2'-DEOXYURIDINE AND 5-FLUOROURACIL IN INHIBITING THE GROWTH OF A HUMAN RENAL-CELL CARCINOMA CELL-LINE (RPMI-SE) IN-VITRO
- Creators
- M A Guimaraes - ROSWELL PK CANC INST,GRACE CANC DRUG CTR,DEPT UROL ONCOL,ELM & CARLTON ST,BUFFALO,NY 14263. ROSWELL PK CANC INST,DEPT EXPTL THERAPEUT,BUFFALO,NY 14263. ROSWELL PK CANC INST,DEPT BIOMATH,BUFFALO,NY 14263. NEW YORK STATE DEPT HLTH,BUFFALO,NY 14263.W R Greco - ROSWELL PK CANC INST,GRACE CANC DRUG CTR,DEPT UROL ONCOL,ELM & CARLTON ST,BUFFALO,NY 14263. ROSWELL PK CANC INST,DEPT EXPTL THERAPEUT,BUFFALO,NY 14263. ROSWELL PK CANC INST,DEPT BIOMATH,BUFFALO,NY 14263. NEW YORK STATE DEPT HLTH,BUFFALO,NY 14263.H K Slocum - ROSWELL PK CANC INST,GRACE CANC DRUG CTR,DEPT UROL ONCOL,ELM & CARLTON ST,BUFFALO,NY 14263. ROSWELL PK CANC INST,DEPT EXPTL THERAPEUT,BUFFALO,NY 14263. ROSWELL PK CANC INST,DEPT BIOMATH,BUFFALO,NY 14263. NEW YORK STATE DEPT HLTH,BUFFALO,NY 14263.R P Huben - ROSWELL PK CANC INST,GRACE CANC DRUG CTR,DEPT UROL ONCOL,ELM & CARLTON ST,BUFFALO,NY 14263. ROSWELL PK CANC INST,DEPT EXPTL THERAPEUT,BUFFALO,NY 14263. ROSWELL PK CANC INST,DEPT BIOMATH,BUFFALO,NY 14263. NEW YORK STATE DEPT HLTH,BUFFALO,NY 14263.Y M Rustum - ROSWELL PK CANC INST,GRACE CANC DRUG CTR,DEPT UROL ONCOL,ELM & CARLTON ST,BUFFALO,NY 14263. ROSWELL PK CANC INST,DEPT EXPTL THERAPEUT,BUFFALO,NY 14263. ROSWELL PK CANC INST,DEPT BIOMATH,BUFFALO,NY 14263. NEW YORK STATE DEPT HLTH,BUFFALO,NY 14263.
- Resource Type
- Journal article
- Publication Details
- International journal of oncology, Vol.4(1), pp.137-141
- Publisher
- INT JOURNAL ONCOLOGY
- DOI
- 10.3892/ijo.4.1.137
- PMID
- 21566903
- ISSN
- 1019-6439
- eISSN
- 1791-2423
- Number of pages
- 5
- Language
- English
- Date published
- 01/01/1994
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359586402771
Metrics
17 Record Views