Journal article
THE GENETICS OF COLORECTAL CANCER
The Surgical clinics of North America, Vol.77(1), pp.175-195
1997
DOI: 10.1016/S0039-6109(05)70538-7
PMID: 9092109
Abstract
Advances in molecular biology have greatly clarified our understanding of the pathophysiology of colorectal cancer development. A genetic model has been devised that associates a progression of genetic alterations with advancing stages of the adenoma-carcinoma sequence. The identification of essential genetic alterations during colorectal cancer development also has practical clinical application in the development of presymptomatic diagnostic tests, prognostic tests, and potential novel sites of tumor-specific therapy.
This article reviews the genetic alterations that are believed to play an important role in the development of sporadic and hereditary forms of colorectal cancer as well as highlights their potential utility in clinical practice, particularly in the field of presymptomatic diagnostic testing for hereditary forms of colorectal cancer.
Details
- Title: Subtitle
- THE GENETICS OF COLORECTAL CANCER
- Creators
- James R Howe - Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa (JRH)José G Guillem - Colorectal Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (JGG)
- Resource Type
- Journal article
- Publication Details
- The Surgical clinics of North America, Vol.77(1), pp.175-195
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0039-6109(05)70538-7
- PMID
- 9092109
- ISSN
- 0039-6109
- eISSN
- 1558-3171
- Language
- English
- Date published
- 1997
- Academic Unit
- Surgery
- Record Identifier
- 9984051867302771
Metrics
22 Record Views