TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis

Bethany Brunton; Kai Rogers; Elisabeth K Phillips; Rachel B Brouillette; Ruayda Bouls; Noah S Butler; Wendy Maury

doi:10.1371/journal.pntd.0006983

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TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis

Journal article

Open access

TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis

Bethany Brunton, Kai Rogers, Elisabeth K Phillips, Rachel B Brouillette, Ruayda Bouls, Noah S Butler and Wendy Maury

PLoS neglected tropical diseases, Vol.13(6), pp.e0006983-e0006983

06/26/2019

DOI: 10.1371/journal.pntd.0006983

PMCID: PMC6615641

PMID: 31242184

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Abstract

T cell immunoglobulin mucin domain-1 (TIM-1) is one of a number of phosphatidylserine (PS) receptors that mediate clearance of apoptotic bodies by binding PS on the surface of dead or dying cells. Enveloped viruses mimic apoptotic bodies by exposing PS on the outer leaflet of the viral membrane. While TIM-1 has been shown to serve as an adherence factor/receptor for filoviruses in tissue culture, limited studies have investigated the role of TIM-1 as a receptor in vivo. Here, we sought to determine if TIM-1 was critical for Ebola virus glycoprotein-mediated infection using a BSL2 model virus. We demonstrate that loss of TIM-1 expression results in decreased virus load late during infection and significantly reduced virus-elicited mortality. These findings provide evidence that TIM-1 serves as an important receptor for Ebola virus in vivo. Blocking TIM-1/EBOV interactions may be effective antiviral strategy to reduce viral load and pathogenicity at late times of EBOV infection.

Medicine and Health Sciences

Biology and life sciences

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Title: Subtitle: TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis
Creators: Bethany Brunton
Kai Rogers
Elisabeth K Phillips
Rachel B Brouillette
Ruayda Bouls
Noah S Butler
Wendy Maury
Resource Type: Journal article
Publication Details: PLoS neglected tropical diseases, Vol.13(6), pp.e0006983-e0006983
DOI: 10.1371/journal.pntd.0006983
PMID: 31242184
PMCID: PMC6615641
NLM abbreviation: PLoS Negl Trop Dis
ISSN: 1935-2727
eISSN: 1935-2735
Publisher: Public Library of Science; San Francisco, CA USA
Grant note: R01 Ai077519 / ; T32 GM 067795 / ;
Alternative title: TIM-1 enhances Ebola virus pathogenesis
Language: English
Date published: 06/26/2019
Academic Unit: Microbiology and Immunology
Record Identifier: 9984001160302771

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