Journal article
TISSUE-SPECIFIC EFFECTS OF N6 DELTA2-ISOPENTENYL) ADENOSINE ON INCORPORATION OF PRECURSORS INTO NUCLEIC-ACIDS AND PROTEIN IN RATS AND MICE
Cancer research (Chicago, Ill.), Vol.32(6), p.1315
01/01/1972
PMID: 5030830
Abstract
In rats and mice, N6-(Δ2-isopentenyl) adenosine affected the incorporation of thymidine-3H, uridine-3H, and phenylalanine-14C into DNA, RNA, and protein, respectively, in a different manner in different tissues. Thus, in spleen the incorporation of these precursors was uniformly inhibited. In liver the incorporation of precursor into protein was inhibited more extensively and more rapidly than those into DNA and RNA, while in intestinal mucosa, inhibition of precursor incorporation into DNA was more pronounced than those into RNA and protein. In rat thymus the incorporation of precursors into macromolecules was stimulated severalfold above control values. Both stimulatory and inhibitory effects were time and dose dependent.
Details
- Title: Subtitle
- TISSUE-SPECIFIC EFFECTS OF N6 DELTA2-ISOPENTENYL) ADENOSINE ON INCORPORATION OF PRECURSORS INTO NUCLEIC-ACIDS AND PROTEIN IN RATS AND MICE
- Creators
- Y RustumE Mihich
- Resource Type
- Journal article
- Publication Details
- Cancer research (Chicago, Ill.), Vol.32(6), p.1315
- Publisher
- Amer Assoc Cancer Research
- PMID
- 5030830
- ISSN
- 0008-5472
- eISSN
- 1538-7445
- Number of pages
- 0
- Language
- English
- Date published
- 01/01/1972
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359845702771
Metrics
9 Record Views