Journal article
TOR Signaling Pathway in Cardiac Aging and Heart Failure
Biomolecules (Basel, Switzerland), Vol.11(2), p.168
01/27/2021
DOI: 10.3390/biom11020168
PMID: 33513917
Abstract
Mechanistic Target of Rapamycin (mTOR) signaling is a key regulator of cellular metabolism, integrating nutrient sensing with cell growth. Over the past two decades, studies on the mTOR pathway have revealed that mTOR complex 1 controls life span, health span, and aging by modulating key cellular processes such as protein synthesis, autophagy, and mitochondrial function, mainly through its downstream substrates. Thus, the mTOR pathway regulates both physiological and pathological processes in the heart from embryonic cardiovascular development to maintenance of cardiac homeostasis in postnatal life. In this regard, the dysregulation of mTOR signaling has been linked to many age-related pathologies, including heart failure and age-related cardiac dysfunction. In this review, we highlight recent advances of the impact of mTOR complex 1 pathway and its regulators on aging and, more specifically, cardiac aging and heart failure.
Details
- Title: Subtitle
- TOR Signaling Pathway in Cardiac Aging and Heart Failure
- Creators
- Nastaran Daneshgar - Department of Pathology, University of Iowa, Iowa City, IA 52242, USAPeter S Rabinovitch - Department of Pathology, University of Washington, Seattle, WA 98195, USADao-Fu Dai - Department of Pathology, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Biomolecules (Basel, Switzerland), Vol.11(2), p.168
- DOI
- 10.3390/biom11020168
- PMID
- 33513917
- NLM abbreviation
- Biomolecules
- eISSN
- 2218-273X
- Publisher
- MDPI
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: K08 HL145138
- Language
- English
- Date published
- 01/27/2021
- Academic Unit
- Pathology; Iowa Neuroscience Institute; Radiation Oncology
- Record Identifier
- 9984070604702771
Metrics
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