Journal article
TRAF family molecules in T cells: Multiple receptors and functions
Journal of leukocyte biology, Vol.107(6), pp.907-915
06/01/2020
DOI: 10.1002/JLB.2MR1119-397R
PMCID: PMC7239704
PMID: 31749173
Abstract
The TNFR superfamily of receptors, the major focus of the recent TNFR Superfamily Conference held in June 2019, employ the TNFR-associated factor (TRAF) family of adaptor proteins in key aspects of their signaling pathways. Although many early studies investigated TRAF functions via exogenous overexpression in nonhematopoietic cell lines, it has subsequently become clear that whereas TRAFs share some overlap in function, each also plays unique biologic roles, that can be highly context dependent. This brief review summarizes the current state of knowledge of functions of each of the TRAF molecules that mediate important functions in T lymphocytes: TRAFs 1, 2, 3, 5, and 6. Due to our current appreciation of the contextual nature of TRAF function, our focus is upon findings made specifically in T lymphocytes. Key T cell functions for each TRAF are detailed, as well as future knowledge gaps of interest and importance.
Details
- Title: Subtitle
- TRAF family molecules in T cells: Multiple receptors and functions
- Creators
- Tina Arkee - University of IowaGail A. Bishop - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of leukocyte biology, Vol.107(6), pp.907-915
- DOI
- 10.1002/JLB.2MR1119-397R
- PMID
- 31749173
- PMCID
- PMC7239704
- NLM abbreviation
- J Leukoc Biol
- ISSN
- 0741-5400
- eISSN
- 1938-3673
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- AI123107; P30CA086862; T32 AI007485; T32 GM007337 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32HL007344 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) I01BX001702 / Veterans Affairs; US Department of Veterans Affairs I01 BX001702 / Veterans' Administration; US Department of Veterans Affairs T32GM007337 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 06/01/2020
- Academic Unit
- Microbiology and Immunology; President; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984297328802771
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