Journal article
TRAF proteins in CD40 signaling
Advances in experimental medicine and biology, Vol.597, pp.131-151
2007
DOI: 10.1007/978-0-387-70630-6_11
PMID: 17633023
Abstract
The tumor necrosis factor receptor (TNFR) superfamily molecule CD40 is expressed by a wide variety of cell types following activation signals, and constitutively on B lymphocytes, macrophages, and dendritic cells. CD40 signals to cells stimulate kinase activation, gene expression, production of a antibody and a variety of cytokines, expression or upregulation of surface molecules, and protection or promotion of apoptosis. Initial steps in CD40-mediated signal cascades involve the interactions of CD40 with various members of the TNFR-associated factor (TRAF) family of cytoplasmic proteins. This review summarizes current understanding of the nature of these interactions, and how they induce and regulate CD40 functions.
Details
- Title: Subtitle
- TRAF proteins in CD40 signaling
- Creators
- Gail A Bishop - Department of Microbiology, Interdisciplinary Graduate Program in Immunology, University of Iowa and the Iowa City VAMC, Iowa City, Iowa 52242, USA. gail-bishop@uiowa.eduCarissa R MoorePing XieLaura L StunzZachary J Kraus
- Resource Type
- Journal article
- Publication Details
- Advances in experimental medicine and biology, Vol.597, pp.131-151
- Publisher
- United States
- DOI
- 10.1007/978-0-387-70630-6_11
- PMID
- 17633023
- eISBN
- 0387706305; 9780387706306
- ISSN
- 0065-2598
- Language
- English
- Date published
- 2007
- Academic Unit
- Microbiology and Immunology; President
- Record Identifier
- 9984002399302771
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