Journal article
TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development
Proceedings of the National Academy of Sciences - PNAS, Vol.110(52), pp.21107-21112
12/24/2013
DOI: 10.1073/pnas.1314859111
PMCID: PMC3876204
PMID: 24324158
Abstract
Induction of tolerance to self-antigens in developing T cells depends on medullary thymic epithelial cells (mTECs), whose development, in turn, requires signals from mature single-positive (SP) thymocytes, a bidirectional interdependence termed cross-talk. We have probed the mechanism that underlies this requirement for cross-talk. Strikingly, selective deletion in thymic epithelial cells of TNF receptor-associated factor 3 (TRAF3), an inhibitor of nonclassical NF-kB signaling, resulted in development of normal numbers of fully mature mTECs in the complete absence of SP thymocytes. Thus, mTEC development can, in fact, occur in the absence of cross-talk with SP thymocytes, and the role of thymocytes is in overcoming TRAF3-imposed inhibition. We conclude that TRAF3 plays a central role in regulation of mTECs by imposing requirements for T cell cross-talk.
Details
- Title: Subtitle
- TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development
- Creators
- S. Rhiannon Jenkinson - National Institutes of HealthJoy A Williams - National Institutes of HealthHyein Jeon - National Institutes of HealthJingjing Zhang - National Institutes of HealthTakeshi Nitta - University of TokushimaIzumi Ohigashi - University of TokushimaMichael Kruhlak - National Institutes of HealthSaulius Zuklys - University of BaselSusan Sharrow - National Institutes of HealthAnthony Adams - National Institutes of HealthLarry Granger - National Institutes of HealthYongwon Choi - University of Pennsylvania School of MedicineUlrich Siebenlist - National Institute of Allergy and Infectious DiseaseGail A Bishop - University of IowaGeorg A Hollander - University of OxfordYousuke Takahama - University of TokushimaRichard J Hodes - National Institutes of Health
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.110(52), pp.21107-21112
- DOI
- 10.1073/pnas.1314859111
- PMID
- 24324158
- PMCID
- PMC3876204
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- National Academy of Sciences
- Alternative title
- TRAF3 enforces thymic cross-talk and development
- Language
- English
- Date published
- 12/24/2013
- Academic Unit
- Microbiology and Immunology; President
- Record Identifier
- 9984001129102771
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