TRAF3, ubiquitination, and B-lymphocyte regulation

Wai W Lin; Bruce S Hostager; Gail A Bishop

doi:10.1111/imr.12299

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TRAF3, ubiquitination, and B-lymphocyte regulation

Journal article

Open access

Peer reviewed

TRAF3, ubiquitination, and B-lymphocyte regulation

Wai W Lin, Bruce S Hostager and Gail A Bishop

Immunological reviews, Vol.266(1), pp.46-55

07/2015

DOI: 10.1111/imr.12299

PMCID: PMC4473794

PMID: 26085206

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http://doi.org/10.1111/imr.12299View

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Abstract

The signaling adapter protein tumor necrosis factor receptor (TNFR)-associated factor 3 (TRAF3) is both modified by and contributes to several types of ubiquitination events. TRAF3 plays a variety of context-dependent regulatory roles in all types of immune cells. In B lymphocytes, TRAF3 contributes to regulation of signaling by members of both the TNFR superfamily and innate immune receptors. TRAF3 also plays a unique cell type-specific and critical role in the restraint of B-cell homeostatic survival, a role with important implications for both B-cell differentiation and the pathogenesis of B-cell malignancies. This review focuses upon the relationship between ubiquitin and TRAF3, and how this contributes to multiple functions of TRAF3 in the regulation of signal transduction, transcriptional activation, and effector functions of B lymphocytes.

Signal Transduction - immunology

Ubiquitination

Animals

Humans

TNF Receptor-Associated Factor 3 - metabolism

B-Lymphocytes, Regulatory - immunology

Immunity, Innate

Details

Title: Subtitle: TRAF3, ubiquitination, and B-lymphocyte regulation
Creators: Wai W Lin - The Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA
Bruce S Hostager - Department of Pediatrics, University of Iowa, Iowa City, IA, USA
Gail A Bishop - VA Medical Center, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Immunological reviews, Vol.266(1), pp.46-55
DOI: 10.1111/imr.12299
PMID: 26085206
PMCID: PMC4473794
NLM abbreviation: Immunol Rev
ISSN: 0105-2896
eISSN: 1600-065X
Publisher: England
Grant note: R01 AI28847 / NIAID NIH HHS P30 ES005605 / NIEHS NIH HHS R01 AI028847 / NIAID NIH HHS CA97274 / NCI NIH HHS CA099997 / NCI NIH HHS I01 BX001702 / BLRD VA R01 CA099997 / NCI NIH HHS P30 CA086862 / NCI NIH HHS P50 CA097274 / NCI NIH HHS
Language: English
Date published: 07/2015
Academic Unit: Microbiology and Immunology; President
Record Identifier: 9984002397502771

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