TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells

Vladimir P Badovinac; Kelly A Nordyke Messingham; Thomas S Griffith; John T Harty

doi:10.4049/jimmunol.177.2.999

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TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells

Journal article

Peer reviewed

TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells

Vladimir P Badovinac, Kelly A Nordyke Messingham, Thomas S Griffith and John T Harty

The Journal of immunology (1950), Vol.177(2), pp.999-1006

07/15/2006

DOI: 10.4049/jimmunol.177.2.999

PMID: 16818756

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Abstract

In this study, we investigated the role of TRAIL in Ag-specific CD8 T cell homeostasis after viral infection. TRAIL deficiency does not influence the kinetics of the Ag-specific CD8 T cell responses, and CD8 T cells in TRAIL-deficient mice were able to expand, contract, and generate functional memory cell numbers that were indistinguishable from TRAIL-sufficient wild-type CD8 T cells after acute lymphocytic choriomeningitis virus infection. Interestingly, the ability of "helpless" CD8 T cells to retain their memory phenotypic and functional (i.e., secondary expansion) characteristics was prolonged in TRAIL-deficient mice compared with wild-type CD4-depleted controls. However, TRAIL deficiency only delayed, but did not prevent, the eventual erosion in the quality of helpless memory CD8 T cells, and that correlated with their inability to respond to a second round of Ag-driven proliferation. These data, which suggest that CD4 help consists of both TRAIL-dependent and -independent components, may help to resolve the current controversy between the early programming and maintenance models that were put forward to explain the role of CD4 T cell help in Ag-specific CD8 T cell homeostasis.

Lymphocytic choriomeningitis virus - immunology

CD8-Positive T-Lymphocytes - pathology

Cell Proliferation

Tumor Necrosis Factor-alpha - genetics

Lymphocyte Depletion

Tumor Necrosis Factor-alpha - deficiency

Lymphocytic Choriomeningitis - immunology

Cell Differentiation - genetics

Lymphocytic Choriomeningitis - metabolism

Membrane Glycoproteins - physiology

TNF-Related Apoptosis-Inducing Ligand

Time Factors

Apoptosis Regulatory Proteins - deficiency

T-Lymphocytes, Helper-Inducer - immunology

T-Lymphocytes, Helper-Inducer - cytology

Apoptosis Regulatory Proteins - genetics

CD8-Positive T-Lymphocytes - metabolism

Epitopes, T-Lymphocyte - immunology

Immunologic Memory - genetics

Immunologic Memory - immunology

T-Lymphocytes, Helper-Inducer - metabolism

Lymphocytic Choriomeningitis - pathology

Mice, Inbred C57BL

Homeostasis - immunology

Immunophenotyping

Membrane Glycoproteins - genetics

Mice, Knockout

Cell Differentiation - immunology

Animals

CD8-Positive T-Lymphocytes - virology

Tumor Necrosis Factor-alpha - physiology

Apoptosis Regulatory Proteins - physiology

Mice

CD8-Positive T-Lymphocytes - immunology

Homeostasis - genetics

Membrane Glycoproteins - deficiency

Details

Title: Subtitle: TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells
Creators: Vladimir P Badovinac - Department of Microbiology, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
Kelly A Nordyke Messingham
Thomas S Griffith
John T Harty
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.177(2), pp.999-1006
DOI: 10.4049/jimmunol.177.2.999
PMID: 16818756
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Publisher: United States
Grant note: P01 AI 60699 / NIAID NIH HHS R01 AI 059752 / NIAID NIH HHS R01 AI 46653 / NIAID NIH HHS R01 AI 50073 / NIAID NIH HHS R01 AI 42767 / NIAID NIH HHS R01 CA 109446 / NCI NIH HHS
Language: English
Date published: 07/15/2006
Academic Unit: Dermatology; Microbiology and Immunology; Pathology
Record Identifier: 9984025584102771

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