Journal article
Tachyarrhythmias During Hospitalization for COVID‐19 or Multisystem Inflammatory Syndrome in Children and Adolescents
Journal of the American Heart Association, Vol.11(20), pp.e025915-e025915
10/18/2022
DOI: 10.1161/JAHA.122.025915
PMCID: PMC9673680
PMID: 36250670
Abstract
Background Cardiac complications related to COVID‐19 in children and adolescents include ventricular dysfunction, myocarditis, coronary artery aneurysm, and bradyarrhythmias, but tachyarrhythmias are less understood. The goal of this study was to evaluate the frequency, characteristics, and outcomes of children and adolescents experiencing tachyarrhythmias while hospitalized for acute severe COVID‐19 or multisystem inflammatory syndrome in children. Methods and Results This study involved a case series of 63 patients with tachyarrhythmias reported in a public health surveillance registry of patients aged <21 years hospitalized from March 15, 2020, to December 31, 2021, at 63 US hospitals. Patients with tachyarrhythmias were compared with patients with severe COVID‐19–related complications without tachyarrhythmias. Tachyarrhythmias were reported in 22 of 1257 patients (1.8%) with acute COVID‐19 and 41 of 2343 (1.7%) patients with multisystem inflammatory syndrome in children. They included supraventricular tachycardia in 28 (44%), accelerated junctional rhythm in 9 (14%), and ventricular tachycardia in 38 (60%); >1 type was reported in 12 (19%). Registry patients with versus without tachyarrhythmia were older (median age, 15.4 [range, 10.4–17.4] versus 10.0 [range, 5.4–14.8] years) and had higher illness severity on hospital admission. Intervention for treatment of tachyarrhythmia was required in 37 (59%) patients and included antiarrhythmic medication (n=31, 49%), electrical cardioversion (n=11, 17%), cardiopulmonary resuscitation (n=8, 13%), and extracorporeal membrane oxygenation (n=9, 14%). Patients with tachyarrhythmias had longer hospital length of stay than those who did not, and 9 (14%) versus 77 (2%) died. Conclusions Tachyarrhythmias were a rare complication of acute severe COVID‐19 and multisystem inflammatory syndrome in children and adolescents and were associated with worse clinical outcomes, highlighting the importance of close monitoring, aggressive treatment, and postdischarge care.
Details
- Title: Subtitle
- Tachyarrhythmias During Hospitalization for COVID‐19 or Multisystem Inflammatory Syndrome in Children and Adolescents
- Creators
- Audrey Dionne - Boston Children's HospitalKevin G. Friedman - Boston Children's HospitalCameron C. Young - Boston Children's HospitalMargaret M. Newhams - Boston Children's HospitalSuden Kucukak - Boston Children's HospitalAshley M. Jackson - Centers for Disease Control and PreventionJulie C. Fitzgerald - University of PennsylvaniaLaura S. Smallcomb - Medical University of South CarolinaSabrina Heidemann - Central Michigan UniversityGwenn E. McLaughlin - University of MiamiKatherine Irby - Arkansas Children's HospitalTamara T. Bradford - Louisiana State University Health Sciences Center New OrleansSteven M. Horwitz - Rutgers, The State University of New JerseyLaura L. Loftis - Texas Children's HospitalVijaya L. Soma - Division of Infectious Diseases, Department of Pediatrics New York University Grossman School of Medicine and Hassenfeld Children’s Hospital New York NYCourtney M. Rowan - Riley Hospital for ChildrenMichele Kong - University of Alabama at BirminghamNatasha B. Halasa - Vanderbilt University Medical CenterKeiko M. Tarquinio - Children's Healthcare of AtlantaAdam J. Schwarz - Children's Hospital of Orange CountyJanet R. Hume - University of MinnesotaShira J. Gertz - Saint Barnabas Medical CenterKatharine N. Clouser - Hackensack University Medical CenterChristopher L. Carroll - Connecticut Children's Medical CenterKari Wellnitz - University of IowaMelissa L. Cullimore - Children's Hospital & Medical CenterSule Doymaz - SUNY Downstate Health Sciences UniversityEmily R. Levy - Mayo Clinic in FloridaKatri V. Typpo - University of ArizonaAmanda N. Lansell - Rainbow Babies & Children's HospitalAndrew D. Butler - St. Christopher's Hospital for ChildrenJoseph D. Kuebler - Golisano Children's HospitalLaura D. Zambrano - Centers for Disease Control and PreventionAngela P. Campbell - Centers for Disease Control and PreventionManish M. Patel - Centers for Disease Control and PreventionAdrienne G. Randolph - Boston Children's HospitalJane W. Newburger - Boston Children's HospitalOvercoming COVID‐19 Investigators
- Resource Type
- Journal article
- Publication Details
- Journal of the American Heart Association, Vol.11(20), pp.e025915-e025915
- DOI
- 10.1161/JAHA.122.025915
- PMID
- 36250670
- PMCID
- PMC9673680
- NLM abbreviation
- J Am Heart Assoc
- ISSN
- 2047-9980
- eISSN
- 2047-9980
- Language
- English
- Date published
- 10/18/2022
- Academic Unit
- Critical Care; Stead Family Department of Pediatrics
- Record Identifier
- 9984353848702771
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